SpringerBriefs in Biochemistry and Molecular Biology

Gene Therapy for HIV

From Inception to a Possible Cure

Authors: Bauer, Gerhard, Anderson, Joseph S.

  • Contributors include scientists who developed the first clinical applications of stem-cell gene therapy for HIV
  • Outlines a path for a possible functional cure for HIV
  • Comprises a thorough and methodical explanation of the basics of gene therapy
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eBook $39.99
price for USA (gross)
  • ISBN 978-1-4939-0434-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $54.99
price for USA
  • ISBN 978-1-4939-0433-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV.

Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients.

In Gene Therapy for HIV, Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In addition, the Brief provides a thorough and methodical explanation of the basics of gene therapy, gene therapy vector development, in vitro and in vivo models for HIV gene therapy and clinical applications of HIV gene therapy, including Good Manufacturing Practices.

Table of contents (9 chapters)

Buy this book

eBook $39.99
price for USA (gross)
  • ISBN 978-1-4939-0434-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $54.99
price for USA
  • ISBN 978-1-4939-0433-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Gene Therapy for HIV
Book Subtitle
From Inception to a Possible Cure
Authors
Series Title
SpringerBriefs in Biochemistry and Molecular Biology
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Gerhard Bauer and Joseph S. Anderson
eBook ISBN
978-1-4939-0434-1
DOI
10.1007/978-1-4939-0434-1
Softcover ISBN
978-1-4939-0433-4
Series ISSN
2211-9353
Edition Number
1
Number of Pages
VIII, 72
Number of Illustrations and Tables
3 illustrations in colour
Topics