MicroRNA in Development and in the Progression of Cancer

Editors: Singh, Shree Ram, Rameshwar, Pranela (Eds.)

  • Provides a more complete understanding of miRNAs function
  • Explore how miRNAs regulate normal development, diseases including cancers and stem cells fate
  • Presents the great potential of miRNAs in CSCs and potential therapeutic advances for cancer
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eBook $149.00
price for USA (gross)
  • ISBN 978-1-4899-8065-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4899-8064-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4939-4491-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.

Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.

About the authors

Dr. Shree Ram Singh is a Staff Scientist for the Mouse Cancer Genetics Program at the National Cancer Institute. 

Dr. Pranela Rameshwar is a Professor of the Department of Medicine at UMDNJ-New Jersey Medical School. See attached CV for additional details.

Table of contents (19 chapters)

  • miRNA Biogenesis and Function

    Olena, Abigail F. (et al.)

    Pages 3-28

  • MicroRNAs in Cancer Progression

    Andrews, Omozusi (et al.)

    Pages 29-46

  • MicroRNA, DNA Repair, and Cancer

    Hu, Hailiang

    Pages 47-66

  • Role of MicroRNAs in Stem Cell Regulation and Tumorigenesis in Drosophila

    Rager, Stephanie (et al.)

    Pages 69-80

  • MicroRNAs in Stem Cells and Cancer Stem Cells

    Bibber, Bernadette (et al.)

    Pages 81-101

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4899-8065-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4899-8064-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4939-4491-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
MicroRNA in Development and in the Progression of Cancer
Editors
  • Shree Ram Singh
  • Pranela Rameshwar
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4899-8065-6
DOI
10.1007/978-1-4899-8065-6
Hardcover ISBN
978-1-4899-8064-9
Softcover ISBN
978-1-4939-4491-0
Edition Number
1
Number of Pages
XIII, 407
Number of Illustrations and Tables
9 b/w illustrations, 38 illustrations in colour
Topics