Stem Cell Biology and Regenerative Medicine

Endogenous Stem Cell-Based Brain Remodeling in Mammals

Editors: Junier, Marie-Pierre, Kernie, Steven G. (Eds.)

  • Highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles
  • Discusses possible ways endogenous regenerative potential might be manipulated for medical purposes
  • Examines the endogenous reparative potential of the brain, including its limitations
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eBook $149.00
price for USA (gross)
  • ISBN 978-1-4899-7399-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4899-7398-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4899-7843-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This text highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our understanding of ongoing brain development throughout the lifespan and serve to introduce the concept of brain plasticity following injury. The second part is devoted to the endogenous reparative potential of the brain, including its limitations, and articles focusing on defined pathologies (e.g. anoxia/hypoxia, epilepsy, traumatic brain injury and stress) in animal models and in humans pinpoint eventual ways these pathologies might be manipulated. The third and final focuses on the "dark side" of stem cells for brain repair or of the manipulation of spontaneous adaptive events after injury (e.g. genomic instability, sensitization to cancerous transformation and defective neural networks).

About the authors

Dr. Steven G. Kernie is an Associate Professor of Pediatrics and Pathology & Cell Biology at Columbia University in New York and Chief of Critical Care Medicine at Morgan Stanley Children’s Hospital at Columbia University Medical Center. His laboratory is interested in how the brain repairs itself following injury. The presence of adult neural stem and progenitor cells in the mammalian brain has awakened new interest and optimism in potential treatment for a variety of acquired brain disorders. The Kernie lab is investigating how adult neural stem and progenitor cells participate in injury-induced remodeling and in identifying genes and drugs that might be important in augmenting their contribution. In order to do this, they have generated a variety of transgenic mice that allow for temporally controlled alterations in the endogenous stem cell population in order to optimize the post-injury remodeling that occurs.

Dr. Marie-Pierre Junier is Research Director at Inserm and co-PI of team Glial Plasticity for the Center of Research Neuroscience Paris Seine at the University Pierre et Marie Curie. Her team showed the permissiveness of astrocytes to re-programming into immature states akin to neural progenitors or neural stem cells. It further demonstrated that these plastic capabilities of astrocytes sensitize them to cancerous transformation. The team is now using cancer stem cells isolated from human adult and pediatric gliomas to understand their differences from normal human neural stem cells. Combining proteomic, metabolic and epigenetic approaches, the team aims at developing new therapeutic strategies against these devastating cancers.

Reviews

From the book reviews:

“A book of interest to researchers studying neurogenesis and regeneration and repair of the nervous tissue after injury. For neurologists, neurosurgeons and biologists.” (Pediatric Endocrinology Reviews (PER), Vol. 12 (1), September, 2014)

Table of contents (10 chapters)

  • Introduction

    Junier, Marie-Pierre (et al.)

    Pages 1-3

  • Structural Plasticity in Adult Nervous System: An Historic Perspective

    Sotelo, Constantino (et al.)

    Pages 5-41

  • Impact of Injured Tissue on Stem Cell Fate

    Fleiss, Bobbi (et al.)

    Pages 43-56

  • Role of Neural Stem and Progenitor Cells in the Adaptation of the Brain to Injury

    Hong, Sue (et al.)

    Pages 57-85

  • Role of Adult Neurogenesis in Seizure-Induced Hippocampal Remodeling and Epilepsy

    Althaus, Alison L. (et al.)

    Pages 87-104

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4899-7399-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4899-7398-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4899-7843-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Endogenous Stem Cell-Based Brain Remodeling in Mammals
Editors
  • Marie-Pierre Junier
  • Steven G. Kernie
Series Title
Stem Cell Biology and Regenerative Medicine
Copyright
2014
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4899-7399-3
DOI
10.1007/978-1-4899-7399-3
Hardcover ISBN
978-1-4899-7398-6
Softcover ISBN
978-1-4899-7843-1
Series ISSN
2196-8985
Edition Number
1
Number of Pages
VIII, 230
Number of Illustrations and Tables
2 b/w illustrations, 19 illustrations in colour
Topics