DNA Tumor Viruses

1. Front Matter

   Pages i-xxiv

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2. The Hamster Polyomavirus

   • Siegfried Scherneck, Jean Feunteun

   Pages 1-14

3. Simian Virus 40 Large T Antigen Induces Chromosome Damage that Precedes and Coincides with Complete Neoplastic Transformation

   • F. Andrew Ray

   Pages 15-26

4. Transformation by Polyomaviruses

   • Daniel T. Simmons

   Pages 27-50

5. Association of BK and JC Human Polyomaviruses and SV40 with Human Tumors

   • Paolo Monini, Laura de Lellis, Giuseppe Barbanti-Brodano

   Pages 51-73

6. Association of Simian Virus 40 with Rodent and Human Mesotheliomas

   • Michele Carbone, Paola Rizzo, Harvey I. Pass

   Pages 75-90

7. Immortalization of Keratinocytes by Human Papillomaviruses

   • Craig D. Woodworth, Joseph A. DiPaolo

   Pages 91-109

8. Cooperation between Bovine Papillomaviruses and Dietary Carcinogens in Cancers of Cattle

   • Maria E. Jackson, M. Saveria Campo

   Pages 111-122

9. Papillomaviruses as Promoting Agents in Human Epithelial Tumors

   • Christa Cerni, Christian Seelos

   Pages 123-155

10. Vaccines against Human Papillomaviruses and Associated Tumors

    • Lionel Crawford

    Pages 157-169

11. The Complex Role of Hepatitis B Virus in Human Hepatocarcinogenesis

    • Marie Annick Buendia, Pascal Pineau

    Pages 171-193

12. Transformation and Tumorigenesis Mediated by the Adenovirus E1A and E1B Oncogenes

    • Robert P. Ricciardi

    Pages 195-225

13. Current Developments in the Molecular Biology of Marek’s Disease Virus

    • Meihan Nonoyama, Akiko Tanaka

    Pages 227-238

14. Oncogenic Transformation of T Cells by Herpesvirus saimiri

    • Peter G. Medveczky

    Pages 239-252

15. Transformation and Mutagenic Effects Induced by Herpes Simplex Virus Types 1 and 2

    • Laure Aurelian

    Pages 253-280

16. Herpes Simplex Virus as a Cooperating Agent in Human Genital Carcinogenesis

    • Dario Di Luca, E. Caselli, E. Cassai

    Pages 281-293

17. Human Cytomegalovirus

    • K. Radsak, H. Kern, B. Reis, M. Reschke, T. Mockenhaupt, M. Eickmann

    Pages 295-312

18. Association of Human Herpesvirus 6 with Human Tumors

    • Dario Di Luca, Riccardo Dolcetti

    Pages 313-326

19. Molecular Mechanisms of Transformation by Epstein-Barr Virus

    • Nancy S. Sung, Joseph S. Pagano

    Pages 327-346

20. Epstein-Barr Virus

    • Layla Karimi, Dorothy H. Crawford

    Pages 347-373

DNA tumor viruses have long been useful experimental models of carcinogenesis and have elucidated several important mechanisms of cell transformation. Re­ search in recent years has shown that human tumors have a multifactorial nature and that some DNA tumor viruses may playa key role in their etiology. The aim of this book is to assess our knowledge of DNA tumor viruses by reviewing animal models, mechanisms of transformation, association with human tumors, and possi­ bilities of prevention and control by vaccination. Animal models of tumor virology have contributed significantly to our under­ standing of the epidemiology and pathogenesis of virus-induced tumors. Bovine papillomaviruses induce papillomas in the intestine of cattle. The papillomas undergo a transition to carcinomas in cows feeding on bracken fern, which pro­ duces a toxin with radiomimetic and immunosuppressive functions. This example of cooperation between a virus and chemical carcinogens parallels the cooperative role of human papillomaviruses (HPVs) and herpes simplex virus type 2 (HSV-2) with environmental carcinogens in the pathogenesis of cervical cancer. Likewise, hepatocarcinomas appearing in woodchucks chronically infected by woodchuck hepatitis virus (WIN) provide strong support for the relationship between hepatitis B virus (HBV) infection and human hepatocellular carcinoma. Also, the fact that WIN DNA integrates closely to cellular oncogenes suggests a possible molecular mechanism for the tumorigenesis induced by HBV.

• Pathogene
• development
• protein
• tumorigenesis
• virus

• Institute of Microbiology, School of Medicine, University of Ferrara, Ferrara, Italy

  Giuseppe Barbanti-Brodano

• University of Pisa, Pisa, Italy

  Mauro Bendinelli

• University of South Florida, Tampa, USA

  Herman Friedman

Policies and ethics