Poly(Ethylene Glycol) Chemistry

1. Front Matter

   Pages i-xxi

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2. Introduction to Biotechnical and Biomedical Applications of Poly(Ethylene Glycol)

   • J. Milton Harris

   Pages 1-14

3. Water Structure of PEG Solutions by Differential Scanning Calorimetry Measurements

   • Kris P. Antonsen, Allan S. Hoffman

   Pages 15-28

4. Molecular Simulation of Protein-PEG Interaction

   • Kap Lim, James N. Herron

   Pages 29-56

5. PEG-Derivatized Ligands with Hydrophobic and Immunological Specificity

   • Donald E. Brooks, James M. Van Alstine, Kim A. Sharp, S. Jill Stocks

   Pages 57-71

6. Affinity Partitioning in PEG-Containing Two-Phase Systems

   • Göte Johansson

   Pages 73-84

7. Aqueous Two-Phase Partitioning on an Industrial Scale

   • Folke Tjerneld

   Pages 85-102

8. PEG-Modified Protein Hybrid Catalyst

   • Kohji Yoshinaga, Hitoshi Ishida, Takashi Sagawa, Katsutoshi Ohkubo

   Pages 103-114

9. PEG-Coupled Semisynthetic Oxidases

   • Tetsuya Yomo, Itaru Urabe, Hirosuke Okada

   Pages 115-125

10. Preparation and Properties of Monomethoxypoly(Ethylene Glycol)-Modified Enzymes for Therapeutic Applications

    • F. M. Veronese, P. Caliceti, O. Schiavon, L. Sartore

    Pages 127-137

11. Suppression of Antibody Responses by Conjugates of Antigens and Monomethoxypoly(Ethylene Glycol)

    • Alec H. Sehon

    Pages 139-151

12. Toxicity of Bilirubin and Detoxification by PEG-Bilirubin Oxidase Conjugate

    • Hiroshi Maeda, Masami Kimura, Ikuharu Sasaki, Yoshihiko Hirose, Toshimitsu Konno

    Pages 153-169

13. PEG-Modified Hemoglobin as an Oxygen Carrier

    • Kwang Nho, Samuel Zalipsky, Abraham Abuchowski, Frank F. Davis

    Pages 171-182

14. Bovine Collagen Modified by PEG

    • W. Rhee, J. Carlino, S. Chu, H. Higley

    Pages 183-198

15. Poly(Ethylene Oxide) and Blood Contact

    • Edward W. Merrill

    Pages 199-220

16. Properties of Immobilized PEG Films and the Interaction with Proteins

    • C.-G. Gölander, James N. Herron, Kap Lim, P. Claesson, P. Stenius, J. D. Andrade

    Pages 221-245

17. Protein Adsorption to and Elution from Polyether Surfaces

    • Wayne R. Gombotz, Wang Guanghui, Thomas A. Horbett, Allan S. Hoffman

    Pages 247-261

18. Poly(Ethylene Glycol) Gels and Drug Delivery

    • N. B. Graham

    Pages 263-281

19. PEO-Modified Surface-In Vitro, Ex Vivo, and In Vivo Blood Compatibility

    • Ki Dong Park, Sung Wan Kim

    Pages 283-301

20. Immobilization of Proteins via PEG Chains

    • Krister Holmberg, Karin Bergström, Maj-Britt Stark

    Pages 303-324

The idea for this book came from discussions among participants in a symposium on biotechnical applications at the "Pacifichem 89" meeting in Honolulu. It was the majority opinion of this group that a volume dedicated to biotechnical and biomedical applications of PEG chemistry would enhance research and development in this area. Though the book was conceived at the Honolulu meeting, it is not a proceedings of this symposium. Several groups who did not participate in this meeting are repre­ sented in the book, and the book incorporates much work done after the meeting. The book does not include contributions in all related areas to which PEG chemistry has been applied. Several invited researchers declined to parti.:ipate, and there is not enough space in this single volume to properly cover all submissions. Chapter I-an overview of the topic-discusses in brief applications not given detailed coverage in specifically devoted chapters. The following topics are covered: introduction to and fundamental properties of PEG and derivatives in Chapters 1-3; separations using aqueous polymer two-phase partitioning in Chapters 4-6; PEG-proteins as catalysts in biotechnical applications in Chapters 7 and 8; biomedical applications of PEG-proteins in Chapters 9-13; PEG­ modified surfaces for a variety of biomedical and biotechnical applications in Chapters 14-20; and synthesis of new PEG derivatives in Chapters 21 and 22.

• antibody
• antigen
• enzymes
• protein
• research

• Department of Chemistry, University of Alabama in Huntsville, Huntsville, USA

  J. Milton Harris

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