Prostate Cancer: New Horizons in Research and Treatment

1. Front Matter

   Pages i-1

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2. Pathology of prostate cancer

   • Mingxin Che, David Grignon

   Pages 3-17

3. Prostate cancer susceptibility genes: Many studies, many results, no answers

   • Nina N. Nupponen, John D. Carpten

   Pages 19-28

4. Molecular profiling in prostate cancer

   • F. Feroze-Merzoug, M. S. Schober, Y. Q. Chen

   Pages 29-35

5. Chromosomal deletions and tumor suppressor genes in prostate cancer

   • Jin-Tang Dong

   Pages 37-57

6. Role of eicosanoids in prostate cancer progression

   • Daotai Nie, Mingxin Che, David Grignon, Keqin Tang, Kenneth V. Honn

   Pages 59-70

7. Contribution of the androgen receptor to prostate cancer predisposition and progression

   • Grant Buchanan, Ryan A. Irvine, Gerhard A. Coetzee, Wayne D. Tilley

   Pages 71-87

8. Regulation of apoptosis in prostate cancer

   • Sushma Gurumurthy, Krishna Murthi Vasudevan, Vivek M. Rangnekar

   Pages 89-107

9. On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis

   • Elieser Gorelik, Uri Galili, Avraham Raz

   Pages 109-141

10. Metastasis suppression in prostate cancer

    • Erich B. Jaeger, Rajeev S. Samant, Carrie W. Rinker-Schaeffer

    Pages 143-150

11. The urokinase-type plasminogen activator system in prostate cancer metastasis

    • Shijie Sheng

    Pages 151-160

12. Angiogenesis in prostate cancer: Biology and therapeutic opportunities

    • Brian Nicholson, Greg Schaefer, Dan Theodorescu

    Pages 161-183

13. Integrins and prostate cancer metastases

    • Mara Fornaro, Thomas Manes, Lucia R. Languino

    Pages 185-195

14. Prostate carcinoma skeletal metastases: Cross-talk between tumor and bone

    • Evan T. Keller, Jian Zhang, Carlton R. Cooper, Peter C. Smith, Laurie K. McCauley, Kenneth J. Pienta et al.

    Pages 197-213

15. Signal transduction targets in androgen-independent prostate cancer

    • Jian Zhou, Jessica Scholes, Jer-Tsong Hsieh

    Pages 215-226

16. The diet, prostate inflammation, and the development of prostate cancer

    • William G. Nelson, Theodore L. DeWeese, Angelo M. DeMarzo

    Pages 227-240

17. Prostate cancer diagnosis, staging and survival

    • Vivek Narain, Michael L. Cher, David P. Wood Jr.

    Pages 241-251

18. Surgery for prostate cancer: Rationale, technique and outcomes

    • Tracy M. Downs, Christopher J. Kane, Gary D. Grossfeld, Maxwell V. Meng, Peter R. Carroll

    Pages 253-268

19. The future of cancer imaging

    • David A. Benaron

    Pages 269-302

20. Antisense therapy: Current status in prostate cancer and other malignancies

    • Martin Gleave, Hideake Miyake, Uwe Zangemeister-Wittke, Burkhard Jansen

    Pages 303-316

In recent years the pace of research in prostate cancer has increased dramatically. Creative ideas in combination with new and emerging technologies have led to an explosion of discovery. These types of advances in prostate cancer research presage an era of new treatment strategies based on an understanding of the cellular and molecular mechanisms of disease.
In creating this book, we aimed to cover a broad "bench to bedside" research spectrum ranging from: genetic, molecular and cellular analyses to epidemiological studies, refinements in local treatment strategies and new biologically based non-hormonal treatments for systemic disease.
Researchers and clinicians will find in this book a group of timely and clinically relevant chapters on prostate cancer research and treatment.

• Staging
• angiogenesis
• apoptosis
• carcinoma
• imaging
• surgery

• The Barbara Ann Karmanos Cancer Institute, Detroit, USA

  Michael L. Cher

• Wayne State University School of Medicine, Detroit, USA

  Avraham Raz, Kenneth V. Honn

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