Hormone Signaling

1. Front Matter

   Pages i-xiii

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2. Fundamental Mechanisms in Signaling

   1. Front Matter

      Pages 1-1

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   2. Protein Phosphorylation and Protein-Protein Interactions

      • Vincent Goffin, Paul A. Kelly

      Pages 3-19

   3. Control of Signaling by Tyrosine Phosphatases

      • Yu Zhao, Zhong-Yin Zhang

      Pages 21-36

   4. Spatio-Temporal Parameters: The Case of the MAP Kinase Pathway

      • Véronique Volmat, Jacques Pouysségur

      Pages 37-53

3. Receptor Tyrosine Kinases

   1. Front Matter

      Pages 55-55

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   2. The EGF Receptor Signaling System

      • Alan Wells

      Pages 57-79

   3. Insulin and Insulin-Like Growth Factor-1 Receptors and Signaling Pathways: Similarities and Differences

      • Derek LeRoith, Michael J. Quon, Yehiel Zick

      Pages 81-99

4. Cytokine Receptors

   1. Front Matter

      Pages 101-101

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   2. The JAK-STAT Pathway

      • Warren J. Leonard

      Pages 103-120

   3. Prolactin and Growth Hormone Receptors

      • Li-yuan Yu-Lee, Sébastien Jeay

      Pages 121-143

   4. Erythropoietin, Thrombopoietin and Leptin Receptors

      • Fabrice Gouilleux

      Pages 145-178

5. G Protein-Coupled Receptors

   1. Front Matter

      Pages 179-179

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   2. G Proteins and G Protein-Coupled Receptors

      • Michael A. Shetzline, Marc G. Caron

      Pages 181-197

   3. Gonadotropin and TSH Receptors

      • Nicolas de Roux, Beate Doeker, Edwin Milgrom

      Pages 199-219

   4. Endothelin G Protein-Coupled Receptors

      • Gastone G. Nussdorfer, Gian Paolo Rossi

      Pages 221-237

6. Nuclear Receptors

   1. Front Matter

      Pages 239-239

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   2. Signal Transduction and Structure of Nuclear Receptors

      • William Bourguet, Pierre Germain, Hinrich Gronemeyer

      Pages 241-267

   3. Estrogen Receptor Beta

      • Zhang Weihua, Guojun Cheng, Ling Wang, Hideki Sakaguchi, Margaret Warner, Jan-Åke Gustafsson

      Pages 269-282

   4. Sensors for Metabolic Control

      • Béatrice Desvergne, Liliane Michalik, Walter Wahli

      Pages 283-304

Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis.
The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.

• EGF receptor
• G protein-coupled receptors
• TSH receptors
• cytokine receptors
• erythropoietin
• estrogen action
• estrogen receptor
• growth hormone receptors
• insulin
• leptin receptors
• metabolic control
• protein phosphorylation
• signaling system
• spatio-temporal parameters
• thrombopoietin
• metabolic disease
• diabetes

• Inserm Unit 344, Molecular Endocrinology, Faculty of Medicine Necker, Paris, France

  Vincent Goffin, Paul A. Kelly

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