Biological Membranes

A Molecular Perspective from Computation and Experiment

Editors: Merz, Kenneth M., Roux, Benoit (Eds.)

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About this book

The interface between a living cell and the surrounding world plays a critical role in numerous complex biological processes. Sperm/egg fusion, virus/cell fusion, exocytosis, endocytosis, and ion permeation are a few examples of processes involving membranes. In recent years, powerful tools such as X-ray crystal­ lography, electron microscopy, nuclear magnetic resonance, and infra-red and Raman spectroscopy have been developed to characterize the structure and dy­ namics of biomembranes. Despite this progress, many of the factors responsible for the function of biomembranes are still not well understood. The membrane is a very complicated supramolecular liquid-crystalline structure that is largely composed of lipids, forming a bilayer, to which proteins and other biomolecules are anchored. Often, the lipid bilayer environment is pictured as a hydropho­ bic structureless slab providing a thermodynamic driving force to partition the amino acids of a membrane protein according to their solubility. However, much of the molecular complexity of the phospholipid bilayer environment is ignored in such a simplified view. It is likely that the atomic details of the polar head­ group region and the transition from the bulk water to the hydrophobic core of the membrane are important. An understanding of the factors responsible for the function of biomembranes thus requires a better characterization at the molec­ ular level of how proteins interact with lipid molecules, of how lipids affect protein structure and of how lipid molecules might regulate protein function.

Table of contents (17 chapters)

  • Time Scales of Lipid Dynamics and Molecular Dynamics

    Pastor, Richard W. (et al.)

    Pages 3-29

  • An Empirical Potential Energy Function for Phospholipids: Criteria for Parameter Optimization and Applications

    Schlenkrich, Michael (et al.)

    Pages 31-81

  • Statistical Mechanics and Monte Carlo Studies of Lipid Membranes

    Scott, H. Larry

    Pages 83-104

  • Strategic Issues in Molecular Dynamics Simulations of Membranes

    Jakobsson, Eric (et al.)

    Pages 105-123

  • The Liquid-Crystallographic Structure of Fluid Lipid Bilayer Membranes

    White, Stephen H. (et al.)

    Pages 127-144

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-1-4684-8580-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.99
price for USA
  • ISBN 978-1-4684-8582-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Biological Membranes
Book Subtitle
A Molecular Perspective from Computation and Experiment
Editors
  • Kenneth M. Merz
  • Benoit Roux
Copyright
1996
Publisher
Birkhäuser Basel
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-8580-6
DOI
10.1007/978-1-4684-8580-6
Softcover ISBN
978-1-4684-8582-0
Edition Number
1
Number of Pages
500
Number of Illustrations and Tables
116 b/w illustrations, 2 illustrations in colour
Topics