Gene Expression

1. Front Matter

   Pages i-xi

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2. The Basic Transcriptional Machinery

   • Stefan G. E. Roberts, Michael R. Green

   Pages 1-24

3. Plasticity of the Differentiated State

   • Helen M. Blau

   Pages 25-42

4. Gene Regulation by Steroid Hormones

   • Miguel Beato

   Pages 43-75

5. Control of Transcription and Cellular Proliferation by cAMP

   • Marc R. Montminy

   Pages 76-92

6. Transcription Factors Controlling Muscle-Specific Gene Expression

   • John J. Schwarz, James F. Martin, Eric N. Olson

   Pages 93-115

7. Gene Expression in Hematopoietic Cells: The β-Globin Gene

   • Beverly M. Emerson

   Pages 116-161

8. Transcriptional Control of Gene Expression in Hepatic Cells

   • Gennaro Ciliberto, Vittorio Colantuoni, Raffaele De Francesco, Vincenzo De Simone, Paolo Monaci, Alfredo Nicosia et al.

   Pages 162-242

9. Transcriptional Control of Pituitary Gene Expression

   • Lars Eyde Theill

   Pages 243-295

10. Back Matter

    Pages 297-303

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This book is the first volume in a new series Progress in Gene Expres­ sion. The control of gene expression is a central-most topic in molecular biology as it deals with the utilization and regulation of gene informa­ tion. As we see huge efforts mounting all over the developed world to understand the structure and organization of several complex eukaryotic genomes in the form of Gene Projects and Genome Centers, we have to remember that without understanding the basic mechanisms that gov­ ern the use of genetic information, much of this effort will not be very productive. Fortunately, however, research during the past seven years on the mechanisms that control gene expression in eukaryotes has been extremely successful in generating a wealth of information on the basic strategies of transcriptional control. (Although regulation of gene ex­ pression is exerted at many different levels, much of the emphasis in this series will be on transcriptional control. A future volume, however, will deal with other levels of regulation). The progress in understanding the control of eukaryotic transcription can only be appreciated by realizing that seven years ago we did not know the primary structure of a single sequence specific transcriptional activator, and those whose primary structures were available (e. g. , homeo­ domain proteins) were not yet recognized to function in this capacity.

• gene expression
• genes
• molecular biology
• transcription

• Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, USA

  Michael Karin

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