DNA-Ligand Interactions

1. Front Matter

   Pages i-x

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2. DNA Structure and Interaction with Small Molecules

   1. DNA Structure: Current Results from Single Crystal X-Ray Diffraction Studies

      • Olga Kennard

      Pages 1-21

   2. One- and Two-Dimensional NMR Studies of the Structures of Simple Sequence DNAs

      • David R. Kearns

      Pages 23-43

   3. The Major and Minor Grooves of the DNA Helix as Conduits for Information Transfer

      • Richard E. Dickerson, Mary L. Kopka, Philip E. Pjura

      Pages 45-62

   4. Unusual DNA Structures and Gene Regulation

      • Robert D. Wells

      Pages 63-83

   5. Specificity and Dynamics of Protein-Nucleic Acid Interactions

      • Dietmar Porschke

      Pages 85-104

   6. DNA and its Counterions: Metal Ions, Amino Acids, Histones and Protamines

      • Juan A. Subirana

      Pages 105-112

   7. Dynamic Aspects of Antibiotic-DNA Interaction

      • Michael Waring

      Pages 113-126

   8. Specific Gene Regulation by Oligodeoxynucleotides Covalently Linked to Intercalating Agents

      • Claude Hélène

      Pages 127-140

   9. Pharmacology of DNA Binding Drugs

      • Bernard Lambert, Jean-Bernard Le Pecq

      Pages 141-157

3. DNA — Protein Interactions: Repressor — Operator Systems

   1. On the Nature and Specificity of DNA-Protein Interactions in the Regulation of Gene Expression

      • Peter H. von Hippel, Otto G. Berg

      Pages 159-171

   2. Searching for the Code of Ideal Protein-DNA-Recognition

      • Norbert Lehming, Juergen Sartorius, Brigitte von Wilcken-Bergmann, Benno Mueller-Hill

      Pages 173-182

   3. trp Repressor, A Crystallographic Study of Allostery in Genetic Regulation

      • P. B. Sigler, A. Joachimiak, R. W. Schevitz, C. L. Lawson, R.-G. Zhang, Z. Otwinowski et al.

      Pages 183-184

   4. Structural Studies of Three DNA Binding Proteins: Catabolite Gene Activator Protein, Resolvase, and the Klenow Fragment of DNA Polymerase I

      • T. A. Steitz, L. Beese, B. Engelman, P. Freemont, J. Friedman, M. Sanderson et al.

      Pages 185-189

   5. A Two-Dimensional NMR Study of the Complex of lac Repressor Headpiece with a 14 Base Pair lac Operator Fragment

      • R. Boelens, R. M. Scheek, R. M. J. N. Lamerichs, J. de Vlieg, J. H. van Boom, R. Kaptein

      Pages 191-215

4. DNA — Protein Interactions: Methylation and Restriction Enzymes

   1. DNA Methylation and Mismatch Repair: Molecular Specificities

      • Miroslav Radman

      Pages 217-224

   2. Recognition of DNA Sequences by Restriction Endonucleases

      • Guenter Maass

      Pages 225-237

   3. Mechanism and Specificity of two Restriction Enzymes, CauI and CauII, that Recognize Asymmetrical DNA Sequences

      • S. Paul Bennett, Stephen E. Halford

      Pages 239-250

   4. Structure of the DNA-EcoRI Endonuclease Recognition Complex

      • John M. Rosenberg, Judith A. McClarin, Christin A. Frederick, Bi-Cheng Wang, John Grable, Herbert W. Boyer et al.

      Pages 251-256

5. Outlook: DNA-Protein Interactions of Complex Systems

   1. Antibodies to Nucleic Acids

      • Marc Leng

      Pages 257-267

This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th. 1986 in the Abbey of Fontevraud (France). The ASI was attended by 112 participants from a wide scientific horizon and from twentyone different countries. It was in some way a follow-up of the ASI held in Maratea. Italy in May 1981 and which was published in the NATO ASI Life Science series as volume 45. While much has been learned about the way the cellular machinery maintains and transmits the genetic heritage. as well as how these processes are regulated. little is Known about how the interactions between the various partners involved are taKing place. The interactions of drugs and proteins with nucleic acids are of evident importance in the understanding of these problems. The spectacular advances in recombinant DNA technology and the increased sophistication of biophysical techniques. in particular >:-ray diffraction and nuclear magnetic resonance. have created a scientific environment which is highly promising for the future of research in molecular biology. These advances permH the serious hope that biology on the molecular level may become a r-eality. Some of the contributions at the ASI presented the most recent advances in this e>:citing field.

• DNA
• biology
• molecular biology
• nucleic acid
• protein
• proteins

• Service de Biochimie, Bat. 142, Département de Biologie, Centre d’Etudes Nucléaires de Saclay, Gif-sur-Yvette Cedex, France

  Wilhelm Guschlbauer

• Institut für Kristallographie, Freie Universität, Berlin 33, German Federal Republic

  Wolfram Saenger

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