Advances in Experimental Medicine and Biology

Mechanisms of Lymphocyte Activation and Immune Regulation

Authors: Gupta, Sudhir, Paul, William E., Fauci, Anthony

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About this book

During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.

Table of contents (30 chapters)

  • The T Cell Receptor: Its Repertoire and Role in Thymocyte Development

    Marrack, Philippa (et al.)

    Pages 1-12

  • Murine T-Cell Receptor Genes

    Davis, M. M. (et al.)

    Pages 13-17

  • Correspondence Between Functionally Significant Sequences in Immunoglobulin and the T Cell Receptor for Antigen

    Hedrick, Stephen M. (et al.)

    Pages 19-27

  • The Early Mitogenic Pathway in Mouse Thymocytes: An Analysis of the Dual Signal Hypothesis

    Metcalfe, James C. (et al.)

    Pages 29-44

  • The Role of the Antigen Receptor/T3 Complex in T-Cell Activation

    Weiss, Arthur (et al.)

    Pages 45-49

Buy this book

eBook $89.00
price for USA (gross)
  • ISBN 978-1-4684-5323-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $119.00
price for USA
  • ISBN 978-1-4684-5325-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Lymphocyte Activation and Immune Regulation
Authors
Series Title
Advances in Experimental Medicine and Biology
Series Volume
213
Copyright
1987
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-5323-2
DOI
10.1007/978-1-4684-5323-2
Softcover ISBN
978-1-4684-5325-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
IX, 337
Topics