Advances in Experimental Medicine and Biology

Biological Reactive Intermediates III

Mechanisms of Action in Animal Models and Human Disease

Editors: Kocsis, J.J., Jollow, D.J., Witmer, C.M., Nelson, J.O., Snyder, R.R. (Eds.)

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About this book

This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.

Table of contents (100 chapters)

  • Years with Elizabeth and James Miller: in Appreciation

    Potter, Van Rensselaer

    Pages 1-9

  • Reactivity and Tumorigenicity of Bay-Region Diol Epoxides Derived from Polycyclic Aromatic Hydrocarbons

    Jerina, D. M. (et al.)

    Pages 11-30

  • Chemistry of Covalent Binding: Studies with Bromobenzene and Thiobenzamide

    Hanzlik, Robert P.

    Pages 31-40

  • Role of Thiols in Protection Against Biological Reactive Intermediates

    Nicotera, Pierluigi (et al.)

    Pages 41-51

  • Role of Parenchymal Versus Non-Parenchymal Cells on the Control of Biologically Reactive Intermediates

    Oesch, Franz (et al.)

    Pages 53-61

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-1-4684-5134-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA
  • ISBN 978-1-4684-5136-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Biological Reactive Intermediates III
Book Subtitle
Mechanisms of Action in Animal Models and Human Disease
Editors
  • James J. Kocsis
  • David J. Jollow
  • Charlotte M. Witmer
  • Judd O. Nelson
  • Robert R. Snyder
Series Title
Advances in Experimental Medicine and Biology
Series Volume
197
Copyright
1986
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-5134-4
DOI
10.1007/978-1-4684-5134-4
Softcover ISBN
978-1-4684-5136-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XV, 1059
Topics