Biological Reactive Intermediates III

1. Front Matter

   Pages i-xv

   PDF

2. Years with Elizabeth and James Miller: in Appreciation

   1. Years with Elizabeth and James Miller: in Appreciation

      • Van Rensselaer Potter

      Pages 1-9

3. Chemistry and Biology of Biological Reactive Intermediates

   1. Reactivity and Tumorigenicity of Bay-Region Diol Epoxides Derived from Polycyclic Aromatic Hydrocarbons

      • D. M. Jerina, J. M. Sayer, S. K. Agarwal, H. Yagi, W. Levin, A. W. Wood et al.

      Pages 11-30

   2. Chemistry of Covalent Binding: Studies with Bromobenzene and Thiobenzamide

      • Robert P. Hanzlik

      Pages 31-40

   3. Role of Thiols in Protection Against Biological Reactive Intermediates

      • Pierluigi Nicotera, Sten Orrenius

      Pages 41-51

   4. Role of Parenchymal Versus Non-Parenchymal Cells on the Control of Biologically Reactive Intermediates

      • Franz Oesch, Mark Lafranconi, Hans-Ruedi Glatt

      Pages 53-61

   5. Significance of Covalent Binding of Chemically Reactive Metabolites of Foreign Compounds to Proteins and Lipids

      • James R. Gillette

      Pages 63-82

4. Biology of Cytochrome P-450 and Related Aspects of the Mixed Function Oxidase

   1. Structure and Function of Cytochrome P-450

      • F. Peter Guengerich, Tsutomu Shimada, Diane R. Umbenhauer, Martha V. Martin, Kunio S. Misono, Linda M. Distlerath et al.

      Pages 83-94

   2. Antibodies as Probes of Cytochrome P450 Isozymes

      • Paul E. Thomas, Linda M. Reik, Sarah L. Maines, Stelvio Bandiera, Dene E. Ryan, Wayne Levin

      Pages 95-106

   3. Age and Sex Differences in Constitutive Forms of Cytochrome P-450 of Rat Liver Microsomes

      • John B. Schenkman, Leonard V. Favreau, Ingela Jansson

      Pages 107-117

   4. Identification of Intratissue Sites for Xenobiotic Activation and Detoxication

      • Jeffrey Baron, Jeffrey M. Voigt, Tyrone B. Whitter, Thomas T. Kawabata, Shirley A. Knapp, F. Peter Guengerich et al.

      Pages 119-144

   5. Monoclonal Antibody-Directed Analysis of Cytochrome P-450

      • Fred K. Friedman, Sang S. Park, Byung J. Song, Kuo C. Cheng, Harry V. Gelboin, T. Fujino

      Pages 145-154

5. Suicide Substrates of Cytochrome P-450

   1. Drug Interactions with Macrolide Antibiotics: Specificity of Pseudo-Suicide Inhibition and Induction of Cytochrome P-450

      • Patrick M. Dansette, Marcel Delaforge, Eric Sartori, Philippe Beaune, Maryse Jaouen, Daniel Mansuy

      Pages 155-162

   2. Isomeric Composition of N-Alkylated Protoporphyrins Produced by Substituted Dihydropyridines in Vivo and in Vitro

      • Francesco De Matteis, Anthony H. Gibbs

      Pages 163-170

6. Characterization and Toxicological Significance of Phase II Enzymes

   1. UDP-Glucuronyltransferases and Their Toxicological Significance

      • Karl Walter Bock, Barbara S. Bock-Hennig, Gösta Fischer, Werner Lilienblum, Gerhard Schirmer

      Pages 171-184

   2. Expression and Sequence Analysis of Rat Liver Glutathione S-Transferase Genes

      • Cecil B. Pickett, Claudia A. Telakowski-Hopkins, Gloria J.-F. Ding, Victor D.-H. Ding

      Pages 185-193

   3. Rat Cytosolic Epoxide Hydrolase

      • Franz Oesch, Ludwig Schladt, Renate Hartmann, Christopher Timms, Walter Wörner

      Pages 195-201

7. Short Communications

   1. Multiplicity of Cytochrome P-450 in Morris Hepatoma

      • Minro Watanabe, Tetsuo Ohmachi, Ikuko Sagami

      Pages 203-212

   2. The Metabolism of Benzene and Phenol by a Reconstituted Purified Phenobarbital-Induced Rat Liver Mixed Function Oxidase System

      • James C. Griffiths, George F. Kalf, Robert Snyder

      Pages 213-222

   3. Comparison of the Metabolism of Benzene and Its Metabolite Phenol in Rat Liver Microsomes

      • Susan K. Gilmour, George F. Kalf, Robert Snyder

      Pages 223-235

This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.

• growth
• metabolism
• nucleic acid
• protein
• proteins
• toxicology

• Thomas Jefferson University, Philadelphia, USA

  James J. Kocsis

• Medical University of South Carolina, Charleston, USA

  David J. Jollow

• Rutgers University, Piscataway, USA

  Charlotte M. Witmer, Robert Snyder

• University of Maryland, College Park, USA

  Judd O. Nelson

Policies and ethics