The Genetics of Aging

1. Front Matter

   Pages i-xvi

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2. Introduction

   1. Introduction

      • Edward L. Schneider

      Pages 1-3

3. Genome Level

   1. Front Matter

      Pages 5-5

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   2. Molecular Genetics of Aging

      • Harvey V. Samis

      Pages 7-25

   3. Cytogenetics of Aging

      • Edward L. Schneider

      Pages 27-52

   4. Aging and DNA-Repair Capability

      • Raymond R. Tice

      Pages 53-89

   5. Somatic Mutations and Aging

      • G. P. Hirsch

      Pages 91-134

4. Organism Level

   1. Front Matter

      Pages 135-135

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   2. Genetics of Aging in Lower Organisms

      • James R. Smith

      Pages 137-149

   3. Evolution of Longevity and Survival Characteristics in Mammals

      • George A. Sacher

      Pages 151-168

5. Human Genetics

   1. Front Matter

      Pages 169-169

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   2. Human Genetic Disorders That Feature Premature Onset and Accelerated Progression of Biological Aging

      • Samuel Goldstein

      Pages 171-224

   3. Parental-Age Effects: Increased Frequencies of Genetically Abnormal Offspring

      • David Kram, Edward L. Schneider

      Pages 225-260

   4. Genetics of Longevity in Man

      • Edmond A. Murphy

      Pages 261-301

   5. A Longitudinal Study of Aging Human Twins

      • Lew Bank, Lissy F. Jarvik

      Pages 303-333

6. Genetic Approaches to Aging Research

   1. Front Matter

      Pages 335-335

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   2. Somatic Cell Genetics in the Analysis of in Vitro Senescence

      • Thomas H. Norwood

      Pages 337-382

   3. Immunogenetics of Aging

      • R. L. Walford, G. S. Smith, P. J. Meredith, K. E. Cheney

      Pages 383-401

   4. Behavior Genetics and Aging

      • Charles L. Goodrick

      Pages 403-415

7. Back Matter

   Pages 417-424

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The Genetics of Aging is divided into several sections in an attempt to provide a logical progression from the level of the genome to the realm of human genetics. The relationship between the genetic material and aging will be thoroughly explored in the initial chapters. These chapters discuss in depth the various theories that have been proposed for the mechanisms of aging at the molecular level and present data which either support or contradict these hypotheses. Subsequent chapters will deal with the genetics of aging in organisms ranging from paramecium to mammals. The largest section of this volume will be devoted to several important areas in human genetics: human genetic disorders which feature premature aging, the effect of human parental aging on the production of genetically abnor­ mal offspring, the genetics of human longevity, and a review of studies on aging human twins. Over the last few decades genetic technology has provided enormous insight into a number of disciplines. Therefore, in the last few chapters, several genetic approaches to the study of aging are discussed: somatic cell genetics, immunogenetics, and behavioral genetics. As the goal of this volume is to present a comprehensive examination of the genetics of aging, most chapters are oriented toward general review of their respective areas. It is my hope that this volume will encourage clinical, biological, and behavioral investigators to turn their attention to the genetic aspects of aging as well as to employ genetic technology to obtain further insight into aging processes.

• DNA
• aging
• alcohol
• chromosome
• cytogenetics
• education
• evolution
• genetics
• growth
• human genetics
• molecular genetics
• mutagen
• mutant
• prenatal diagnosis
• stability

• Gerontology Research Center, National Institute on Aging, Baltimore, USA

  Edward L. Schneider

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