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Table of contents (25 chapters)
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Front Matter
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Methods
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Front Matter
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Concepts and Analysis
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Front Matter
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Patch Clamp Data
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Front Matter
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Keywords
About this book
Single-channel recording has become a widely used tool for the study of ion permeation mechanisms in biological membranes. Whereas the technique might have been considered an "art" after its introduction in 1976, it developed into a relatively simple method after it became possible to obtain high-resistance (several gigaohm) membrane-pipette seals. In the summer of 1982, a course on the technique was held at the Ettore Majorana Center for Scientific Culture in Erice, Sicily. It brought together people from most of the laboratories involved in patch clamping at that time. During the course, it became apparent that the technique had reached a state of maturity. Repeatedly, the opinion was expressed that a detailed description of all the aspects of the technique including representative examples of results should be available. We therefore asked the course instructors, as well as several other colleagues, to provide chapters on selected topics in order to produce this volume. The different variants of patch clamping were described quite extensively in an article by Hamill, Marty, Neher, Sakmann, and Sigworth (Pflugers Archiv 391:85) in 1981. Rather than repeating this survey in an introductory chapter, we chose to reprint that article in the Appendix of this volume (by permission of Springer-Verlag). The methods section will, therefore, go straight into detailed aspects of the technol ogy.
Editors and Affiliations
Bibliographic Information
Book Title: Single-Channel Recording
Editors: Bert Sakmann, Erwin Neher
DOI: https://doi.org/10.1007/978-1-4615-7858-1
Publisher: Springer New York, NY
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eBook Packages: Springer Book Archive
Copyright Information: Plenum Press, New York 1983
Softcover ISBN: 978-1-4615-7860-4Published: 26 April 2012
eBook ISBN: 978-1-4615-7858-1Published: 11 November 2013
Edition Number: 1
Number of Pages: XXII, 504
Number of Illustrations: 136 b/w illustrations
Topics: Neurosciences