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Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV

  • Book
  • © 1985

Overview

Editors:
  1. Michael D. Waters

    1. U.S. Environmental Protection Agency, USA

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  2. Shahbeg S. Sandhu

    1. U.S. Environmental Protection Agency, USA

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  3. Joellen Lewtas

    1. U.S. Environmental Protection Agency, USA

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  4. Larry Claxton

    1. U.S. Environmental Protection Agency, USA

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  5. Gary Strauss

    1. U.S. Environmental Protection Agency, USA

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  6. Stephen Nesnow

    1. U.S. Environmental Protection Agency, USA

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Part of the book series: Environmental Science Research (ESRH, volume 32)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-x
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  2. Keynote Address

    1. Front Matter

      Pages 1-1
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    2. Keynote Address

      • Scott Baker
      Pages 3-5

  3. New Developments and Techniques

    1. Front Matter

      Pages 7-7
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    2. Use of the Microscreen Assay for Airborne Particulate Organic Matter

      • Toby G. Rossman, LeRoy W. Meyer, James P. Butler, Joan M. Daisey
      Pages 9-23

    3. Development of an In Situ Test System for Detection of Mutagens in the Workplace

      • Tong-man Ong, John D. Stewart, James D. Tucker, Wen-Zong Whong
      Pages 25-36

    4. Perturbations of Enzymic Initiation of Excision Repair due to Guanine Modification in DNA

      • Nahum J. Duker
      Pages 37-44

    5. Plant Genetic Assays to Evaluate Complex Environmental Mixtures

      • Michael J. Plewa
      Pages 45-64

    6. Studies with Gaseous Mutagens In Drosophila Melanogaster

      • P. G. N. Kramers, B. Bissumbhar, H. C. A. Mout
      Pages 65-73

    7. Anaphase Aberrations: An in Vitro Test for Assessing the Genotoxicity of Individual Chemicals and Complex Mixtures

      • Richard M. Kocan, David B. Powell
      Pages 75-86

    8. Anaphase Aberrations: An in vivo Measure of Genotoxicity

      • Vincent M. Liguori, Marsha L. Landolt
      Pages 87-98

    9. Measurement of Chemically Induced Mitotic Nondisjunction using a Monochromosomal Human/Mouse Hybrid Cell Line

      • Raghbir S. Athwal, Shahbeg S. Sandhu
      Pages 99-112

    10. Toxicologic Responses to a Complex Coal Conversion By-Product: Mammalian Cell Mutagenicity and Dermal Carcinogenicity

      • Michael L. Cunningham, David A. Haugen, Frederick R. Kirchner, Christopher A. Reilly Jr.
      Pages 113-123

    11. Increased Virus Transformation by Formaldehyde of Hamster Embryo Cells Pretreated with Benzo(A)Pyrene

      • G. G. Hatch, T. M. Anderson
      Pages 125-138

    12. Enhancement of Anchorage-Independent Survival of Retrovirus-Infected Fischer Rat Embryo Cells for Determining the Carcinogenic Potential of Chemical and Physical Agents

      • William A. Suk, Joan E. Humphreys, E. Perry Hays, John D. Arnold
      Pages 139-153

    13. Correlation Between In Vivo Tumorigenesis and In Vitro Cytotoxicity in Cho and V79 Cells after Exposure to Mineral Fibers

      • L. D. Palekar, B. G. Brown, D. L. Coffin
      Pages 155-169

    14. Quality Assurance and Good Laboratory Practice Regulations for Short-Term Bioassays of Complex Mixtures

      • Roberts de Woskin
      Pages 171-179

    15. Generation and Characterization of Complex Gas and Particle Mixtures for Inhalation Toxicologic Studies

      • Michael T. Kleinman, Robert F. Phalen, T. Timothy Crocker
      Pages 181-191

  4. Integrated Assessment

    1. Front Matter

      Pages 193-193
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    2. Nitro Compounds in Environmental Mixtures and Foods

      • Yoshinari Ohnishi, Takemi Kinouchi, Yoshiki Manabe, Hideshi Tsutsui, Hisashi Otsuka, Hiroshi Tokiwa et al.
      Pages 195-204
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Keywords

About this book

With this proceedings of the fourth symposium on complex mixtures, we continue to revise and extend our knowledge of genetic methods for the evaluation of chemical mixtures in the environment. The early chapters of this volume are devoted to new bioassay techniques that are directly applicable to the monitoring of environments contaminated with genotoxic chemicals. Microbiological methods have been further refined to meet the special needs of atmospheric monitoring so that very small samples may now be efficiently tested. New in situ methods utilizing green plants actually avoid many of the usual difficulties of sample collection and preparation and offer special advantages in monitoring wastewater, sludges, and hazardous wastes. Insects also are being employed very effectively in the evaluation of gaseous air pollutants in controlled laboratory investigations. Increased emphasis has been placed on a comprehensive assessment of the potential of complex mixtures t9 cause various kinds of genetic damage. New assays for chromosome structural and numerical aberrations in mammalian cells in vitro have been developed and are being applied in laboratory studies. Efforts to link tests for gene mutation and cell transformation in vitro with assays for tumorigenesis in vivo are contributing to the validation of the short-term testing approach. Studies comparing in vitro and in vivo data on a coal conversion by-product, on polycyclic aromatic hydrocarbons, and on mineral fibers are reported in separate papers. Later chapters are devoted to investigations on the fractionation and biological evaluation of specific chemical components within complex mixtures.

Editors and Affiliations

  • U.S. Environmental Protection Agency, USA

    Michael D. Waters, Shahbeg S. Sandhu, Joellen Lewtas, Larry Claxton, Gary Strauss, Stephen Nesnow

Bibliographic Information

  • Book Title: Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV

  • Editors: Michael D. Waters, Shahbeg S. Sandhu, Joellen Lewtas, Larry Claxton, Gary Strauss, Stephen Nesnow

  • Series Title: Environmental Science Research

  • DOI: https://doi.org/10.1007/978-1-4615-7849-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1985

  • Hardcover ISBN: 978-0-306-42015-3Due: 01 August 1985

  • Softcover ISBN: 978-1-4615-7851-2Published: 14 June 2012

  • eBook ISBN: 978-1-4615-7849-9Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: X, 384

  • Number of Illustrations: 32 b/w illustrations

  • Topics: Physics, general

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