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Cell Adhesion Molecules

Cellular Recognition Mechanisms

  • Book
  • © 1993

Overview

Editors:
  1. Martin E. Hemler

    1. Dana-Farber Cancer Institute, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Enrico Mihich

    1. Roswell Park Cancer Institute, Buffalo, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Pezcoller Foundation Symposia (PFSO, volume 4)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-x
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  2. Transcriptional Regulation of the αIIβ Integrin Gene

    • Gerard Marguerie, Georges Uzan
    Pages 1-11

  3. Integrin Expression and Epithelial Cell Differentiation

    • Vito Quaranta
    Pages 13-27

  4. Fibronectin Mutations in Mice

    • Elisabeth N. Georges, Elizabeth L. George, Helen Rayburn, Richard O. Hynes
    Pages 29-39

  5. General Discussion -- Session I

    • Martin E. Hemler, Enrico Mihich
    Pages 41-43

  6. Regulation of β1 Integrin-Mediated Adhesive Functions

    • Francisco Sánchez-Madrid, Alicia G. Arroyo, Miguel R. Campanero, Paloma Sánchez-Mateos
    Pages 45-61

  7. Elements for a Structural/Functional Model of Human Platelet Plasma Membrane Fibrinogen Receptor, the Glycoprotein IIb/IIIa Complex (Integrin αIIb/β3)

    • Juan José Calvete
    Pages 63-91

  8. Extracellular and Intracellular Functions of vla Proteins

    • Martin E. Hemler, Akihide Masumoto, Bosco M. C. Chan, Paul Kassner, Joaquin Teixidó
    Pages 93-104

  9. Signal Transduction from Leukocyte Integrins

    • Eric J. Brown
    Pages 105-125

  10. Coordinate Role for Proteoglycans and Integrins in Cell Adhesion

    • James B. McCarthy, Amy P. N. Skubitz, Leo T. Furcht, Elizabeth A. Wayner, Joji Iida
    Pages 127-147

  11. Adhesion Molecules at Endothelial Cell to Cell Junctions

    • Maria Grazia Lampugnani, Massimo Resnati, Marco Raiteri, Marco Pittiglio, Luigi Ruco, Elisabetta Dejana
    Pages 149-163

  12. Regulation of T Cell Adhesion with T Cell Differentiation and with Acute Activation by Mip-lβ Cytokine Immobilized on CD44 Proteoglycan

    • Yoshiya Tanaka, David H. Adams, Tamas Schweighoffer, Stephen Shaw
    Pages 165-179

  13. Activation of Lfa-1: The L16 Epitope is a Cation-Binding Reporter

    • Carl G. Figdor, Yvette van Kooyk
    Pages 181-194

  14. Activation-Dependent Regulation of β1 Integrin Expression and Function in Human Natural Killer Cells

    • Angela Gismondi, Fabrizio Mainiero, Gabriella Palmieri, Stefania Morrone, Michele Milella, Mario Piccoli et al.
    Pages 195-208

  15. Interaction of Cytotoxic T Lymphocytes with Autologous Melanoma: Role of Adhesion Molecules and β1 Integrins

    • Andrea Anichini, Roberta Mortarini, Giorgio Parmiani
    Pages 209-219

  16. Tumor Cell-Endothelial Cell Interactions During Blood Borne Metastasis: Role of Specific Adhesion, Motility, and Growth Molecules

    • Garth L. Nicolson, Timothy J. Yeatman, Robert J. Tressler, Timothy V. Updyke, Jun-ichi Hamada, Phillip G. Cavanaugh
    Pages 221-243

  17. Adhesion Mechanisms in Lymphoma and Carcinoma Metastasis

    • Geertje La Rivière, Hans Kemperman, Mariëtte Driessens
    Pages 245-264

  18. Cd44 and Splice Variants of Cd44 in Normal Differentiation and Tumor Progression

    • Peter Herrlich, Wolfgang Rudy, Martin Hofmann, Robert Arch, Margot Zöller, Volker Zawadzki et al.
    Pages 265-288

  19. Back Matter

    Pages 289-294
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Keywords

About this book

The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression.

Editors and Affiliations

  • Dana-Farber Cancer Institute, Boston, USA

    Martin E. Hemler

  • Roswell Park Cancer Institute, Buffalo, USA

    Enrico Mihich

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