Overview
Part of the book series: Developments in Molecular and Cellular Biochemistry (DMCB, volume 35)
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Table of contents (21 chapters)
Keywords
About this book
CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation.
This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.
Editors and Affiliations
Bibliographic Information
Book Title: Protein Kinase CK2 — From Structure to Regulation
Editors: Khalil Ahmed, Olaf-Georg Issinger, Jorge E Allende
Series Title: Developments in Molecular and Cellular Biochemistry
DOI: https://doi.org/10.1007/978-1-4615-1723-8
Publisher: Springer New York, NY
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eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 2001
Hardcover ISBN: 978-0-7923-7666-8Published: 30 June 2002
Softcover ISBN: 978-1-4613-5696-7Published: 22 March 2013
eBook ISBN: 978-1-4615-1723-8Published: 06 December 2012
Edition Number: 1
Number of Pages: V, 187
Additional Information: Reprinted from MOLECULAR AND CELLULAR BIOCHEMISTRY, 227:1-2
Topics: Biochemistry, general