Cancer Drug Discovery and Development

Tumor Metabolome Targeting and Drug Development

Editors: Kanner, Steven (Ed.)

  • Provides expert reviews of multiple metabolic targets covering the glycolytic pathway, Krebs cycle, tumor microenvironment, hypoxia, and therapeutic strategies
  • Explores experimental models for evaluating the tumor metabolome to provide knowledge and access to the field
  • Bridges the fields of cancer cell metabolism, tumor/stroma microenvironments, autophagy, drug discovery and development, and translational application of novel cancer therapies
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eBook $149.00
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  • ISBN 978-1-4614-9545-1
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  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-9544-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4939-5343-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
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About this book

In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.

The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.

About the authors

Dr. Steven B. Kanner is the Vice President of Discovery Biology at Astex Pharmaceuticals. He has been a pharmaceutical research leader with over 20 years of extensive experience in novel target identification and validation, assay development, both small molecule and antibody drug discovery, and expertise in oncology, immunology and inflammation. For more detail, please see the attached CV herewith.

Table of contents (8 chapters)

  • Tumor Cell Metabolic Reprogramming and Drug Targeting

    Kanner, Steven B.

    Pages 1-5

  • Cancer Metabolism: A Nexus of Matter, Energy, and Reactive Oxygen Species

    Bingham, Paul M. (et al.)

    Pages 7-27

  • Regulating Mitochondrial Respiration in Cancer

    Serafim, Teresa L. (et al.)

    Pages 29-73

  • Regulation of Cancer Cell Metabolism by Hypoxia

    Pulkoski-Gross, Ashleigh (et al.)

    Pages 75-108

  • Glucose Metabolism and the Antioxidative Defense System in Cancer Cells: Options for the Application of ROS-based Anticancer Drugs

    Bruchelt, Gernot (et al.)

    Pages 109-130

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4614-9545-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-9544-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4939-5343-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Metabolome Targeting and Drug Development
Editors
  • Steven Kanner
Series Title
Cancer Drug Discovery and Development
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-9545-1
DOI
10.1007/978-1-4614-9545-1
Hardcover ISBN
978-1-4614-9544-4
Softcover ISBN
978-1-4939-5343-1
Series ISSN
2196-9906
Edition Number
1
Number of Pages
VIII, 198
Number of Illustrations and Tables
10 b/w illustrations, 12 illustrations in colour
Topics