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Focal Controlled Drug Delivery

  • Book
  • © 2014

Overview

Editors:
  1. Abraham J. Domb

    1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

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  2. Wahid Khan

    1. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, India

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes fundamental introductory chapters for focal drug delivery
  • Describes drug delivery to body sites/system
  • Provides an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Delivery Science and Technology (ADST)

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Introductory Chapters

    1. Front Matter

      Pages 1-1
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    2. Biodegradable Polymers for Focal Delivery Systems

      • Wahid Khan, Venu Gopala Swami Challa, Robert Langer, Abraham J. Domb
      Pages 3-32

    3. Implantable Medical Devices

      • Wahid Khan, Eameema Muntimadugu, Michael Jaffe, Abraham J. Domb
      Pages 33-59

    4. Systemic Targeting Systems-EPR Effect, Ligand Targeting Systems

      • Prasad V. Pawar, Abraham J. Domb, Neeraj Kumar
      Pages 61-91

    5. Liposomal Formulations for Focal and Targeted Drug Delivery in Cancer and Other Diseases

      • Sean Essex, Vladimir Torchilin
      Pages 93-116

    6. Polymer–Drug Conjugate in Focal Drug Delivery

      • Rajan Swami, Dinesh Kumar, Wahid Khan, Ramakrishna Sistla, Nalini Shastri
      Pages 117-147

    7. Pharmacokinetic and Pharmacodynamic Aspects of Focal and Targeted Delivery of Drugs

      • David Stepensky
      Pages 149-166

  3. Delivery to Body Sites/Systems

    1. Front Matter

      Pages 167-167
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    2. Treatment of Brain Tumors

      • Betty M. Tyler, Gustavo Pradilla, Uri Hadelsberg, Hansen Bow, Ian Suk, Henry Brem
      Pages 169-194

    3. Intranasal Delivery of Neuropeptide-Loaded Nanoparticles and Their Application to Nervous System Therapeutics

      • Michael J. Kubek, Abraham J. Domb, Daniel J. Kubek, Michael C. Veronesi
      Pages 195-213

    4. Focal Drug Delivery in Inner Ear Therapy

      • Jing Zou
      Pages 215-224

    5. Nanotechnology-Based Ophthalmic Drug Delivery System

      • Fahima Dilnawaz, Sanjeeb Kumar Sahoo
      Pages 225-241

    6. Site-Specific Ocular Nucleic Acid Delivery

      • Ravi S. Shukla, Kun Cheng
      Pages 243-262

    7. Topical Iontophoresis for Targeted Local Drug Delivery to the Eye and Skin

      • Taís Gratieri, Yogeshvar N. Kalia
      Pages 263-284

    8. Local Drug Delivery to the Oral Cavity

      • Sheeba Qureshi, Wahid Khan, Michael Perez-Davidi, Ervin I Weiss, Nurit Beyth, Abraham J. Domb
      Pages 285-304

    9. Focal Drug Delivery for Management of Oral Infections

      • Nurit Beyth, Orith Haramaty, David Polak
      Pages 305-327

    10. Segmental-Dependent Drug Absorption and Delivery: The Stomach

      • Omri Wolk, Arik Dahan
      Pages 329-341

    11. Segmental-Dependent Drug Absorption and Delivery: The Intestinal Tract

      • Omri Wolk, Arik Dahan
      Pages 343-357

    12. Nanotechnology Applications in Local Arterial Drug Delivery

      • Dipti Deshpande, Aziza Jamal-Allial, Kinjal Sankhe, Mansoor Amiji
      Pages 359-385
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Keywords

About this book

The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.

Editors and Affiliations

  • School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  • Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, India

    Wahid Khan

About the editors

ABRAHAM J. DOMB is Professor for Medicinal Chemistry and Biopolymers at the Faculty of Medicine of the Hebrew University in Jerusalem, Israel.  He earned bachelor’s degrees in chemistry, pharmacy and law studies and a Ph.D. in chemistry from Hebrew University. He did his postdoctoral training at MIT and Harvard University and was R&D manager at Nova Pharm in Baltimore between 1988 and 1992. His primary research interests are in biopolymers, controlled drug delivery, cancer therapy, nanoparticulate systems, and forensic sciences.

 

WAHID KHAN obtained his master’s degree and Ph.D. in pharmaceutics at the National Institute of Pharmaceutical & Educational Research (NIPER) in Mohali, India. He worked with Prof. Abraham J. Domb in The Hebrew University of Jerusalem, Israel, for his post-doctoral research. Currently, he is working as Assistant Professor in the Department of Pharmaceutics at NIPER in Hyderabad, India. His experience includes areas ranging from drug delivery and drug targeting to nanomedicine and biodesign of implantable medical devices.

Bibliographic Information

  • Book Title: Focal Controlled Drug Delivery

  • Editors: Abraham J. Domb, Wahid Khan

  • Series Title: Advances in Delivery Science and Technology

  • DOI: https://doi.org/10.1007/978-1-4614-9434-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Controlled Release Society 2014

  • Hardcover ISBN: 978-1-4614-9433-1Published: 18 February 2014

  • Softcover ISBN: 978-1-4899-7965-0Published: 27 August 2016

  • eBook ISBN: 978-1-4614-9434-8Published: 17 February 2014

  • Series ISSN: 2192-6204

  • Series E-ISSN: 2192-6212

  • Edition Number: 1

  • Number of Pages: XVII, 700

  • Number of Illustrations: 25 b/w illustrations, 75 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology

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