Proteases in Health and Disease

1. Front Matter

   Pages i-xv

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2. Molecular and Biochemical Aspects of Proteases

   1. Front Matter

      Pages 1-1

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   2. An Overview of Endoplasmic Reticulum Calpain System

      • Krishna Samanta, Pulak Kar, Tapati Chakraborti, Sajal Chakraborti

      Pages 3-19

   3. Mitochondrial Calpains: Who, What, Where, When and Why?

      • James W. Geddes

      Pages 21-32

   4. Role of Calpains in Calmodulin Regulated Systems

      • Sreejit Parameswaran, Sujeet Kumar, Rajendra K. Sharma

      Pages 33-48

   5. Exercise and Matrix Metalloproteases in Health and Disease: A Brief Overview

      • Soni Shaikh, Animesh Chowdhury, Alok K. Banerjee, Jaganmay Sarkar, Sajal Chakraborti

      Pages 49-62

   6. Regulation of Chondrocyte Matrix Metalloproteinase Gene Expression

      • Charles J. Malemud

      Pages 63-77

   7. Microbial Source of Fibrinolytic Protease and Its Biotechnological Potential

      • Ratnakar R. Chitte

      Pages 79-88

   8. Aspartic Proteolytic Inhibitors Induce Cellular and Biochemical Alterations in Fungal Cells

      • André L. S. Santos, Lys A. Braga-Silva, Bianca A. Silva, Vanila F. Palmeira, Roberta S. Valle, Érika A. Abi-chacra et al.

      Pages 89-119

   9. Cysteine Proteases of Human Malaria Parasites

      • Kailash C. Pandey

      Pages 121-134

   10. Proteases as Virulence Factors in Leishmania: Focus on Serine Proteases as Possible Therapeutic Targets

       • Partha Das, MD Nur Alam, Tripti De, Tapati Chakraborti

       Pages 135-161

   11. An Updated Inventory on Properties, Pathophysiology and Therapeutic Potential of Snake Venom Thrombin-Like Proteases

       • Ashis K. Mukherjee

       Pages 163-180

   12. Macrocyclic Protease Inhibitors Constrained into a β-Strand Geometry

       • Ashok D. Pehere, Andrew D. Abell

       Pages 181-192

3. Involvement of Proteases in Disease Processes

   1. Front Matter

      Pages 193-193

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   2. Regulation of MT1-MMP Activation and Its Relevance to Disease Processes

      • Soumitra Roy, Tapati Chakraborti, Animesh Chowdhury, Kuntal Dey, Sajal Chakraborti

      Pages 195-213

   3. Role of Proteases During Intra-erythrocytic Developmental Cycle of Human Malaria Parasite Plasmodium falciparum

      • Sumit Rathore, Shaifali Jain, MohD Asad, Gaurav Datta, Pawan Malhotra, Asif Mohmmed

      Pages 215-242

   4. Proteases in Vibrio cholerae and Their Role in Pathogenesis

      • Amit Pal, Sun Nyunt Wai

      Pages 243-256

   5. ADAMTS13: The von Willebrand Factor Cleaving Protease and Its Role in Thrombotic Thrombocytopenic Purpura

      • Surbhi Saini, Tal Schiller, Andrew Wu, Chava Kimchi-Sarfaty

      Pages 257-276

   6. Role of Proteases and Their Tissue Inhibitors in Pregnancy Outcome

      • Sudhir C. Roy

      Pages 277-287

   7. Matrix Metalloproteinases in Bone Health and Disease

      • Stav Simsa-Maziel, Dalit Sela-Donenfeld, Efrat Monsonego-Ornan

      Pages 289-312

In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.

• Biochemistry
• Proteases
• Signal transduction
• Proteomics

• Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, India

  Sajal Chakraborti

• Institute of Cardiovascular Sciences, University of Manitoba, St. Boniface Hospital Research Centre, Winnipeg, Canada

  Naranjan S. Dhalla

Dr. Sajal Chakraborti is a Senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases in regulating pulmonary vascular tone under oxidant- and calcium-signaling phenomena. He has been engaged in teaching and research in biochemistry for the past 35 years.

Dr. Naranjan Dhalla is a Distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary research and education for promoting the scientific basis of cardiology, as well as training of professional manpower for combating heart disease for over 40 years.

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