Neuromethods

Nanoscale Imaging of Synapses

New Concepts and Opportunities

Editors: Nägerl, Valentin, Triller, Antoine (Eds.)

  • Timeliness – Superresolution methods are beginning to transform neurobiological research
  • Relevance – Progress in synapse research hinges on advances in superresolution imaging
  • Competence – Chapters are written by leading innovators and practitioners in the field of bioimaging
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eBook $89.00
price for USA (gross)
  • ISBN 978-1-4614-9179-8
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase
Hardcover $119.00
price for USA
  • ISBN 978-1-4614-9178-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $119.00
price for USA
  • ISBN 978-1-4939-4918-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Synapses underlie rapid and flexible neural communication in the brain and they hold the key to understanding higher brain functions in health and disease. Because they are very small and highly dynamic, it is very difficult to study them with traditional techniques. Fortunately, recent ground-breaking advances in optical microscopy (e.g. STED, PALM, STORM, SIM) have greatly improved our ability to image living synapses at the nanoscale, even down to the level of single molecules. The proposed volume brings together leading researchers to review these exciting new techniques and their application in neurobiological research. It will explain and discuss the basic principles behind the various superresolution modalities, how they are implemented, what their scope and limitations are etc. In addition, several key research discoveries on synapses enabled by these novel approaches will be highlighted.

Table of contents (11 chapters)

  • Nanoscale Imaging of Protein Molecules at the Postsynaptic Density

    Chen, Xiaobing (et al.)

    Pages 1-21

  • Electron Tomography for the Study of Synaptic Ultrastructure in Fixed Brain Sections

    Burette, Alain C. (et al.)

    Pages 23-41

  • Flash-and-Freeze Electron Microscopy: Coupling Optogenetics with High-Pressure Freezing

    Watanabe, Shigeki (et al.)

    Pages 43-57

  • Investigating AMPA Receptor Diffusion and Nanoscale Organization at Synapses with High-Density Single-Molecule Tracking Methods

    Constals, Audrey (et al.)

    Pages 59-74

  • Visualizing the Ultrastructures and Dynamics of Synapses by Single-Molecule Nanoscopy

    Specht, Christian G. (et al.)

    Pages 75-91

Buy this book

eBook $89.00
price for USA (gross)
  • ISBN 978-1-4614-9179-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.00
price for USA
  • ISBN 978-1-4614-9178-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $119.00
price for USA
  • ISBN 978-1-4939-4918-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Nanoscale Imaging of Synapses
Book Subtitle
New Concepts and Opportunities
Editors
  • Valentin Nägerl
  • Antoine Triller
Series Title
Neuromethods
Series Volume
84
Copyright
2014
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-9179-8
DOI
10.1007/978-1-4614-9179-8
Hardcover ISBN
978-1-4614-9178-1
Softcover ISBN
978-1-4939-4918-2
Series ISSN
0893-2336
Edition Number
1
Number of Pages
X, 231
Number of Illustrations and Tables
8 b/w illustrations, 49 illustrations in colour
Topics