Cancer Drug Discovery and Development

Hypoxia and Cancer

Biological Implications and Therapeutic Opportunities

Editors: Melillo, Giovanni (Ed.)

  • ​​Features ​comprehensive and systematic analysis of biological and therapeutic targets associated with intra-tumor hypoxia
  • Focuses on translational aspects associated with intra-tumor hypoxia
  • Explores the opportunities for drug development offered by this unique feature of the tumor microenvironments
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eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-9167-5
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  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-9166-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-5355-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

​​​The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is a topic has been gaining scientific interest over the last few years for its wide involvement in many physiological and pathological processes. 

This volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, along with opportunities for drug development offered by this unique feature of the tumor microenvironment. The ongoing efforts to translate our understanding of the biology underlying intra-tumor hypoxia in viable therapeutic options face many challenges, but this book will provide an opportunity for an in-depth analysis of the fundamental mechanisms implicated in the adaption to low oxygen levels and will scrutinize the potential for opportunities that are being pursued in both research and the drug development industry.

About the authors

Dr. Giovanni Melillo is the Medical Director for the branch of Discovery Medicine at Bristol-Myers Squibb. Prior to his role at BMS, he was the Senior Investigator and Head of the Tumor Hypoxia Lab at the Developmental Therapeutics Program of the National Cancer Institute. He's been investigating hypoxia and its role in tumor progression for over 15 years. He's currently an Associate Editor for several journals, including Journal of Cancer Research and the Journal of Molecular Medicine. He also serves on the Editorial Board of several journals, including Cell Cycle and the Journal of Molecular Cancer, to name a few.

Table of contents (15 chapters)

  • Hypoxia and Breast Cancer Metastasis

    Schito, Luana (et al.)

    Pages 3-19

  • Hypoxia and the DNA Damage Response

    Olcina, Monica M. (et al.)

    Pages 21-41

  • Emerging Roles of Non-Coding RNAs in the Hypoxic Response

    Ivan, Mircea (et al.)

    Pages 43-64

  • Hypoxia and Reactive Oxygen Species

    Görlach, Agnes

    Pages 65-90

  • Hypoxia and Gene Expression

    Bosco, Maria Carla (et al.)

    Pages 91-119

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-9167-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-9166-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-5355-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Hypoxia and Cancer
Book Subtitle
Biological Implications and Therapeutic Opportunities
Editors
  • Giovanni Melillo
Series Title
Cancer Drug Discovery and Development
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-9167-5
DOI
10.1007/978-1-4614-9167-5
Hardcover ISBN
978-1-4614-9166-8
Softcover ISBN
978-1-4939-5355-4
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XIV, 363
Number of Illustrations and Tables
17 b/w illustrations, 36 illustrations in colour
Topics