Advances in Biochemistry in Health and Disease

Role of Proteases in Cellular Dysfunction

Editors: Chakraborti, Sajal, Dhalla, Naranjan S. (Eds.)

  • First volume to comprehensively explore the role of proteases in various diseases
  • Provides information on the pathogenesis of cellular dysfunction, with strong emphasis on identifying proteases and their endogenous inhibitors as targets for drug development
  • Utilizes a multidisciplinary approach to biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases
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eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-9099-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-1-4614-9098-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-1-4939-4634-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues.

Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteasome system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.

About the authors

Sajal Chakraborti is a professor at the University of Kalyani, India.

Naranjan S. Dhalla is a professor at St. Boniface General Hospital  and the University of Manitoba, Canada.

Table of contents (23 chapters)

  • Role of Calpain in Immunobiology of Neurodegenerative Diseases

    Trager, Nicole (et al.)

    Pages 3-15

  • Calpain Interactions with the Protein Phosphatase Calcineurin in Neurodegeneration

    Norris, Christopher M.

    Pages 17-45

  • Involvement of Caspases in the Pathophysiology of Neurodegeneration and Stroke

    Goswami, Alakananda (et al.)

    Pages 47-66

  • Matrix Metalloproteinases in Ischemia–Reperfusion Injury in Brain: Antioxidants as Rescuer

    Sarkar, Sibani (et al.)

    Pages 67-91

  • The Role of Matrix Metalloproteinases in Neurovascular Injury

    Seo, Ji Hae (et al.)

    Pages 93-102

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-9099-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-1-4614-9098-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-1-4939-4634-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Role of Proteases in Cellular Dysfunction
Editors
  • Sajal Chakraborti
  • Naranjan S. Dhalla
Series Title
Advances in Biochemistry in Health and Disease
Series Volume
8
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-9099-9
DOI
10.1007/978-1-4614-9099-9
Hardcover ISBN
978-1-4614-9098-2
Softcover ISBN
978-1-4939-4634-1
Edition Number
1
Number of Pages
XI, 462
Number of Illustrations and Tables
12 b/w illustrations, 46 illustrations in colour
Topics