Current Cancer Research

Molecular Determinants of Head and Neck Cancer

Editors: Burtness, Barbara, Golemis, Erica A. (Eds.)

  • Summarize the unique pathobiology of head and neck cancers
  • Addresses signaling pathways and individual proteins that are important in causing or supporting the aggressive nature of head and neck cancer
  • Covers high throughput studies addressing chromosomal, mutational, and transcriptional changes that characterize SCCHN
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About this book

Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. In the past several years, there have been significant developments in understanding of HNC. It is now recognized that although alcohol and tobacco use has represented the likely predominant cause of SCCHN, the incidence of a second class of SCCHN related to oncogenic human papillomavirus (HPV) infection is increasing, with a four-fold increase in the past 2 decades, and now thought to represent up to 30% of cases. The first effective target for SCCHN, the EGFR-targeting antibody cetuximab, was approved as recently as in 2006; since then, a growing body of research has identified additional signaling pathways as important in disease pathogenesis, and in resistance to treatment. Proteins such as c-Met, Src, and HER2 are emerging as new therapeutic targets, with a considerable ferment in the clinical trial community. As a capstone of research progress, 2011 marked the first reports of high throughput sequencing of SCCHN tumors, with these efforts identifying unexpected players such as Notch as frequent subject of mutation, spawning new hypotheses for future research. This book will be of interest to researchers who are interested in better understanding the biology of head and neck cancers, with the goals of better designing therapies, identifying risk factors, or investigating the molecular basis of the disease.

About the authors

Barbara Burtness, M.D. is Associate Director for Clinical Research at the Fox Chase Cancer Center. She is also a co-leader of the Keystone Program in Head and Neck Cancer. As Chair of the Head and Neck Committee in the Eastern Cooperative Oncology Group and a member of the NCI Head and Neck Steering Committee, she helps shape the national agenda for research on all stages of head and neck cancer.

Erica Golemis, Ph.D. is the Deputy Chief Scientific Officer at the Fox Chase Cancer Center. She is also the Co-Leader of Developmental Therapeutics and Co-Leader of the Head and Neck Cancer Keystone at Fox Chase. Her research seeks to define the changes in cell signaling that occur as tumors spread by metastasis and develop resistance to drugs, with the ultimate goal of inhibiting these processes.

Table of contents (17 chapters)

  • Overview: The Pathobiology of Head and Neck Cancer

    Burtness, Barbara (et al.)

    Pages 1-5

  • Molecular Features and Treatment Modalities of “Classic” Versus Human Papilloma Virus-Associated Head and Neck Cancer

    Mountzios, Giannis (et al.)

    Pages 7-21

  • Epidemiology of HPV in Head and Neck Cancer: Variant Strains, Discrete Protein Function

    Ragin, Camille C. R. (et al.)

    Pages 23-53

  • EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer

    Liu, Hanqing (et al.)

    Pages 55-90

  • The Role of HGF/c-MET in Head and Neck Squamous Cell Carcinoma

    Seiwert, Tanguy Y. (et al.)

    Pages 91-111

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-8815-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-8814-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-4489-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Determinants of Head and Neck Cancer
Editors
  • Barbara Burtness
  • Erica A. Golemis
Series Title
Current Cancer Research
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8815-6
DOI
10.1007/978-1-4614-8815-6
Hardcover ISBN
978-1-4614-8814-9
Softcover ISBN
978-1-4939-4489-7
Series ISSN
2199-2584
Edition Number
1
Number of Pages
IX, 362
Number of Illustrations and Tables
4 b/w illustrations, 40 illustrations in colour
Topics