Current Cancer Research

Advances in Tumor Immunology and Immunotherapy

Editors: Rosenblatt, J., Podack, E., Barber, G.N., Ochoa, A. (Eds.)

  • Most up-to-date volume that explores evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation
  • Highlights early successes as well as failures to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering
  • Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion
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eBook $159.00
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  • ISBN 978-1-4614-8809-5
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Hardcover $209.00
price for USA
  • ISBN 978-1-4614-8808-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-5097-3
  • Free shipping for individuals worldwide
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Rent the ebook  
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About this book

Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets.

Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion.

In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Table of contents (15 chapters)

  • Myeloid-Derived Suppressor Cells in Cancer

    Kyriakopoulos, Christos E. (et al.)

    Pages 3-17

  • The Role of B Cells in Shaping the Antitumor Immune Response

    Zhang, Yu (et al.)

    Pages 19-35

  • Heat-Shock Protein-Based Cancer Immunotherapy

    Schreiber, Taylor H.

    Pages 37-56

  • Activation of NK Cell Responses and Immunotherapy of Cancer

    Weiner, George J.

    Pages 57-66

  • Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay

    Gilboa, Eli

    Pages 67-82

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-8809-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-8808-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-5097-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Advances in Tumor Immunology and Immunotherapy
Editors
  • Joseph Rosenblatt
  • Eckhard Podack
  • Glen N. Barber
  • Augusto Ochoa
Series Title
Current Cancer Research
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8809-5
DOI
10.1007/978-1-4614-8809-5
Hardcover ISBN
978-1-4614-8808-8
Softcover ISBN
978-1-4939-5097-3
Series ISSN
2199-2584
Edition Number
1
Number of Pages
IX, 371
Number of Illustrations and Tables
6 b/w illustrations, 29 illustrations in colour
Topics