Advances in Experimental Medicine and Biology

Systems Analysis of Human Multigene Disorders

Editors: Maltsev, PhD, Natalia, Rzhetsky, Andrey, Gilliam, PhD, T. Conrad (Eds.)

  • High-throughput experimental genomics technologies for data collection
  • Bioinformatics approaches for systems-level analysis of biological systems and prediction of causative multidimensional patterns of inheritance characteristic of multigene disorders
  • Case scenarios of systems-level analysis of multigene disorders
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eBook $149.00
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  • ISBN 978-1-4614-8778-4
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Hardcover $189.00
price for USA
  • ISBN 978-1-4614-8777-7
  • with online files
  • Free shipping for individuals worldwide
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Softcover $189.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: May 15, 2016
  • ISBN 978-1-4939-5194-9
  • Free shipping for individuals worldwide
About this book

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

Table of contents (5 chapters)

  • Wellness and Health Omics Linked to the Environment: The WHOLE Approach to Personalized Medicine

    Gibson, Greg

    Pages 1-14

  • Characterizing Multi-omic Data in Systems Biology

    Mason, Christopher E. (et al.)

    Pages 15-38

  • High-Throughput Translational Medicine: Challenges and Solutions

    Sulakhe, Dinanath (et al.)

    Pages 39-67

  • Computational Approaches for Human Disease Gene Prediction and Ranking

    Zhu, Cheng (et al.)

    Pages 69-84

  • A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization

    Hensing, Thomas (et al.)

    Pages 85-117

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4614-8778-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-8777-7
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: May 15, 2016
  • ISBN 978-1-4939-5194-9
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Systems Analysis of Human Multigene Disorders
Editors
  • Natalia Maltsev, PhD
  • Andrey Rzhetsky
  • T. Conrad Gilliam, PhD
Series Title
Advances in Experimental Medicine and Biology
Series Volume
799
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8778-4
DOI
10.1007/978-1-4614-8778-4
Hardcover ISBN
978-1-4614-8777-7
Softcover ISBN
978-1-4939-5194-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIII, 122
Number of Illustrations and Tables
12 illustrations in colour
Topics