The Genetics of Obesity

Editors: Grant, Struan (Ed.)

  • Comprehensive review of efforts aimed at uncovering genetic variants associated with obesity
  • Covers breakthroughs in syndromic obesity, including Bardet-Biedl and Prader-Willi syndromes
  • Reviews Genome-wide Association Studies and effects on obesity research​
see more benefits

Buy this book

eBook $109.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4614-8642-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4614-8641-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4939-5342-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), h has been more robustly observed by others. Studies from both FTO knock out and FTO overexpression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity.   Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book will give a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). This book will cover this state of the art technology and its application to obesity in great detail. Topics covered will include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.​

Table of contents (7 chapters)

  • Genetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies

    McCormack, Shana E.

    Pages 1-21

  • Genetic Obesity Syndromes

    Farooqi, I. Sadaf (et al.)

    Pages 23-32

  • Genome-Wide Association Studies of Obesity

    Hedman, Åsa K. (et al.)

    Pages 33-53

  • Copy Number Variants and Their Contribution to the Risk of Obesity

    Moustafa, Julia Sarah El-Sayed (et al.)

    Pages 55-70

  • Genetics of Childhood Obesity

    Grant, Struan F. A.

    Pages 71-91

Buy this book

eBook $109.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4614-8642-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4614-8641-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4939-5342-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
The Genetics of Obesity
Editors
  • Struan Grant
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8642-8
DOI
10.1007/978-1-4614-8642-8
Hardcover ISBN
978-1-4614-8641-1
Softcover ISBN
978-1-4939-5342-4
Edition Number
1
Number of Pages
VIII, 128
Number of Illustrations and Tables
11 illustrations in colour
Topics