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Heterogeneity in Asthma

  • Book
  • © 2014

Overview

Editors:
  1. Allan R. Brasier

    1. Institute for Translational Sciences, University of Texas Medical Branch, Galveston, USA

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 795)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xiv
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  2. The Spectrum of Asthma: An Introduction

    1. Front Matter

      Pages 1-4
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    2. Introduction to Asthma and Phenotyping

      • Regina A. Pillai, William J. Calhoun
      Pages 5-15

    3. Epidemiology of Asthma: Prevalence and Burden of Disease

      • Sharon Croisant
      Pages 17-29

    4. Heterogeneity of Asthma in Society

      • Rohit Divekar, William J. Calhoun
      Pages 31-41

    5. Inhaled Environmental Allergens and Toxicants as Determinants of the Asthma Phenotype

      • Kristin Sokol, Sanjiv Sur, Bill T. Ameredes
      Pages 43-73

    6. Current Clinical Diagnostic Tests for Asthma

      • Shiwan Shah, Gulshan Sharma
      Pages 75-80

    7. Management of Asthma: The Current US and European Guidelines

      • Ashwini P. Reddy, Meera R. Gupta
      Pages 81-103

    8. Community-Based Interventions in Asthma

      • Sharon Petronella Croisant, Lauren Scott
      Pages 105-115

    9. Heterogeneity of Response to Therapy

      • William J. Calhoun
      Pages 117-122

  3. Genetics and Genomics in Asthma

    1. Front Matter

      Pages 123-123
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    2. Introduction to Genetics and Genomics in Asthma: Genetics of Asthma

      • Rasika Ann Mathias
      Pages 125-155

    3. Gene Expression Profiling in Asthma

      • Joanne Sordillo, Benjamin A. Raby
      Pages 157-181

    4. Asthma Epigenetics

      • Muhammad T. Salam
      Pages 183-199

  4. Proteomics, Metabolomics, and Systems Biology of Asthma

    1. Front Matter

      Pages 201-201
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    2. Overview

      • John E. Wiktorowicz
      Pages 203-205

    3. Metabolomics in Asthma

      • Bruce A. Luxon
      Pages 207-220

    4. Proteomic Analysis of the Asthmatic Airway

      • John E. Wiktorowicz, Mohammad Jamaluddin
      Pages 221-232

    5. Measurement of the Innate Immune Response in the Airway

      • Allan R. Brasier, Yingxin Zhao
      Pages 233-254

    6. Functional Proteomics for the Characterization of Impaired Cellular Responses to Glucocorticoids in Asthma

      • Konrad Pazdrak, Alexander Kurosky
      Pages 255-270
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About this book

Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling.  These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response.  Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease.  An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma.  This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma.  As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. ​ 

Editors and Affiliations

  • Institute for Translational Sciences, University of Texas Medical Branch, Galveston, USA

    Allan R. Brasier

Bibliographic Information

  • Book Title: Heterogeneity in Asthma

  • Editors: Allan R. Brasier

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-8603-9

  • Publisher: Humana New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2014

  • Hardcover ISBN: 978-1-4614-8602-2Published: 27 October 2013

  • Softcover ISBN: 978-1-4899-7829-5Published: 23 August 2016

  • eBook ISBN: 978-1-4614-8603-9Published: 08 July 2014

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIV, 354

  • Number of Illustrations: 8 b/w illustrations, 25 illustrations in colour

  • Topics: Human Physiology, Molecular Medicine

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