Advances in Experimental Medicine and Biology

Heterogeneity in Asthma

Editors: Brasier, Allan R. (Ed.)

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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eBook $149.00
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  • ISBN 978-1-4614-8603-9
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Hardcover $189.00
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  • ISBN 978-1-4614-8602-2
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Softcover $189.00
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About this book

Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling.  These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response.  Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease.  An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma.  This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma.  As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. ​ 

Table of contents (21 chapters)

  • Introduction to Asthma and Phenotyping

    Pillai, Regina A. (et al.)

    Pages 5-15

  • Epidemiology of Asthma: Prevalence and Burden of Disease

    Croisant, Sharon

    Pages 17-29

  • Heterogeneity of Asthma in Society

    Divekar, Rohit (et al.)

    Pages 31-41

  • Inhaled Environmental Allergens and Toxicants as Determinants of the Asthma Phenotype

    Sokol, Kristin (et al.)

    Pages 43-73

  • Current Clinical Diagnostic Tests for Asthma

    Shah, Shiwan (et al.)

    Pages 75-80

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4614-8603-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-8602-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4899-7829-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Heterogeneity in Asthma
Editors
  • Allan R. Brasier
Series Title
Advances in Experimental Medicine and Biology
Series Volume
795
Copyright
2014
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8603-9
DOI
10.1007/978-1-4614-8603-9
Hardcover ISBN
978-1-4614-8602-2
Softcover ISBN
978-1-4899-7829-5
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIV, 354
Number of Illustrations and Tables
8 b/w illustrations, 25 illustrations in colour
Topics