Protein Deimination in Human Health and Disease

Editors: Nicholas, Anthony, Bhattacharya, Sanjoy (Eds.)

  • Provides a comprehensive book, which does not currently exist, on a rapidly developing field
  • Illustrates the connection between deimination and numerous illnesses, including auto-immune diseases, Alzheimer's, Parkinson's, Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, cancer, periodontitis, glaucoma, spinal cord trauma and peripheral nerve injury
  • Includes contributions from authors in the US, Canada, Europe and Asia
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eBook $159.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4614-8317-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
About this book

Deimination is a relatively new post-translational modification of proteins, whose recognition is ever-increasing. First linked to the pathology of rheumatoid arthritis (RA), deimination is a process by which selected positively charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl arginine deiminase (PAD) family of enzymes.

Although the medical literature is rich with articles about the possible significance of deiminated proteins in RA, Protein Deimination in Human Health and Disease is the first publication to compile this knowledge and the growing amount of new information now known about the presence of deiminated proteins in the eye, skin, hair, gums, lung and nervous system, as well. As a result, this process has now been linked to numerous additional conditions besides RA, including cancer, glaucoma, Alzheimer's disease, Parkinson's disease, multiple sclerosis, spinal cord and peripheral nerve injury, Creutzfeldt-Jakob disease, among many others.

Chronicling the earliest studies of deimination up to the present, this volume distills what is currently known about citrullination of proteins in the human body and is the first book of its kind on the topic.

Table of contents (21 chapters)

  • Physiological Pathways of PAD Activation and Citrullinated Epitope Generation

    Rohrbach, Amanda S. (et al.)

    Pages 1-24

  • From Citrullination to Specific Immunity and Disease in Rheumatoid Arthritis

    Hensvold, Aase Haj (et al.)

    Pages 25-40

  • The Role of Synovial Citrullinated Proteins in the Pathophysiology of Rheumatoid Arthritis

    Beers, Joyce J. B. C. (et al.)

    Pages 41-68

  • Protein Citrullination: The Link Between Rheumatoid Arthritis and Periodontitis?

    Smit, M. J. (et al.)

    Pages 69-82

  • From Genes and Environment to Anti-citrulline Immunity in Rheumatoid Arthritis: The Role of the Lungs

    Makrygiannakis, Dimitris

    Pages 83-96

Buy this book

eBook $159.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4614-8317-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
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Bibliographic Information

Bibliographic Information
Book Title
Protein Deimination in Human Health and Disease
Editors
  • Anthony Nicholas
  • Sanjoy Bhattacharya
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8317-5
DOI
10.1007/978-1-4614-8317-5
Edition Number
1
Number of Pages
XIII, 433
Number of Illustrations and Tables
55 b/w illustrations, 75 illustrations in colour
Topics