Advances in Experimental Medicine and Biology

Gadd45 Stress Sensor Genes

Editors: Liebermann, Dan A., Hoffman, Barbara (Eds.)

  • Provides a comprehensive picture of the unique global role Gadd45 genes play as stress sensors and the molecular pathways involved
  • The functions of Gadd45 proteins are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation
  • Gadd45 proteins are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress
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eBook $109.00
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  • ISBN 978-1-4614-8289-5
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Hardcover $139.00
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  • ISBN 978-1-4614-8288-8
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Softcover $139.00
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About this book

Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  

Table of contents (7 chapters)

  • Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis

    Salvador, Jesús M. (et al.)

    Pages 1-19

  • Gadd45 in Modulation of Solid Tumors and Leukemia

    Hoffman, Barbara (et al.)

    Pages 21-33

  • Gadd45 Proteins: Key Players of Repair-Mediated DNA Demethylation

    Schäfer, Andrea

    Pages 35-50

  • Gadd45 Proteins in Immunity

    Schmitz, Ingo

    Pages 51-68

  • Gadd45 in the Liver: Signal Transduction and Transcriptional Mechanisms

    Tian, Jianmin (et al.)

    Pages 69-80

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-4614-8289-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-4614-8288-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-1-4939-5390-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Gadd45 Stress Sensor Genes
Editors
  • Dan A. Liebermann
  • Barbara Hoffman
Series Title
Advances in Experimental Medicine and Biology
Series Volume
793
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8289-5
DOI
10.1007/978-1-4614-8289-5
Hardcover ISBN
978-1-4614-8288-8
Softcover ISBN
978-1-4939-5390-5
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 134
Number of Illustrations and Tables
7 b/w illustrations, 11 illustrations in colour
Topics