Molecular Genetics of Inflammatory Bowel Disease

Editors: D'Amato, Mauro, Rioux, John D (Eds.)

  • Provides a complete review of existing knowledge of molecular genetics in inflammatory bowel diseases
  • Highlights the latest discoveries from molecular and genome-wide association studies
  • Gives insight into disease pathogenesis and potential targets for pharmaceutical intervention
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eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-8256-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-8255-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-4256-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e.g. psoriasis,  multiple sclerosis, type 1 diabetes and many others).

Table of contents (16 chapters)

  • A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges

    Zhu, Xinjun Cindy (et al.)

    Pages 3-21

  • Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies

    Halfvarson, Jonas

    Pages 23-43

  • Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease

    Mizoguchi, Emiko (et al.)

    Pages 45-83

  • Complex Disease Genes and Their Discovery

    Barrett, Jeffrey C. (et al.)

    Pages 87-97

  • The Genetics of Crohn’s Disease

    Franke, Andre (et al.)

    Pages 99-118

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-8256-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-8255-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-4256-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Genetics of Inflammatory Bowel Disease
Editors
  • Mauro D'Amato
  • John D Rioux
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8256-7
DOI
10.1007/978-1-4614-8256-7
Hardcover ISBN
978-1-4614-8255-0
Softcover ISBN
978-1-4939-4256-5
Edition Number
1
Number of Pages
XIII, 343
Number of Illustrations and Tables
23 illustrations in colour
Topics