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AAPS Advances in the Pharmaceutical Sciences Series

Pharmaco-Imaging in Drug and Biologics Development

Fundamentals and Applications

Editors: Moyer, Brian R., Cheruvu, Narayan P.S., Hu, Tom (Eds.)

  • Provides comprehensive exploration into the drug and biologic development process
  • Benefits scientists across many fields in facilitating the understanding of pharmaco-imaging principles
  • Explains how imaging tools can serve by providing high value data, images and kinetic information
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Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-8247-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-8246-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-5174-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The volume aim to be a comprehensive overview of the drug and biologic development process that is often called “the valley of death” (pre-IND through approval) where high costs of studies and high rates of product failure are part of the drug development landscape. Imaging tools can serve in this period by adding high value data, the images and the kinetic information they can provide, and cost-effective development alternative tools which potentially improve pivotal study designs. Imaging may identify safety issues early such as unwanted organ or tissue distributions, and then can serve advanced development with added certainty of a drug or biologic’s success to senior corporate management and investors. There are numerous textbooks, reference texts and treatises on medical imaging technologies, teaching tools on medical cases and physics books on the science of detector and computer interface systems. Rarely, in each of these are examples of medical imaging protocols and animal models of disease i.e. a text on methodology in drug development is currently unavailable.

About the authors

Mr. Brian R. Moyer is Owner/President of BRMoyer & Associates, LLC, Bedford, NH, consulting in medical imaging, radiation/chemical injury, and PK/TK services. He is under contract as a Sr. Science Advisor for HHS/BARDA, Washington, D.C., for Radiation-Chem countermeasure development. Mr. Moyer earned an M.S. in Pharmacology (Univ. of California, San Francisco), an M.S. in Toxicology (Univ. of San Francisco), and is board-certified in Nuclear Medicine Technology (CNMT).  He has over 40 years in the imaging field with over 80 publications and has contributed toward six drug approvals.

Dr. Narayan Cheruvu is Sr. Principal Clinical Pharmacologist at Covidien, St.Louis, MO.  He earned a B.S. in Pharmacy (Andhra Univ.), an M.S. in Pharmacy (Institute of Technology-Banaras Hindu Univ., India) and a Ph.D. in Pharmaceutical Science (Nebraska Medical Center, Omaha, NE).  Dr Cheruvu has more than 9 years in preclinical/clinical pharmacology, more than 20 publications and has contributed toward three drug approvals.

Dr. Tom C.-C. Hu is a Project Officer at HHS/BARDA, Washington D.C., overseeing contracts for Radiation-Chem countermeasure development and rapid radiation biodosimetry. He is an Asst. Professor of Radiology (Medical College of Georgia) and served as Principal Scientist at GlaxoSmithKline PLC.  Dr. Hu earned a B.S. in Chemistry (Univ. Pittsburgh), an M.S. and Ph.D. in Chemistry (Carnegie Mellon Univ), and an M.B.A (Villanova Univ).  

Table of contents (13 chapters)

  • Imaging Platforms and Drug Development: An Introduction

    Moyer, Brian R.

    Pages 1-43

  • Imaging in Drug Development: Animal Models, Handling and Physiological Constraints

    Stout, David B.

    Pages 45-62

  • Considerations for Preclinical Laboratory Animal Imaging Center Design, Setup, and Management Suitable for Biomedical Investigation for Drug Discovery

    Klaunberg, Brenda A. (et al.)

    Pages 63-94

  • Pharmaco-Imaging in Translational Science and Research

    Freedman, Immanuel

    Pages 95-112

  • The Role of Pharmacokinetics and Allometrics in Imaging: Practical Issues and Considerations

    Moyer, Brian R.

    Pages 113-131

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-8247-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-8246-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-5174-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pharmaco-Imaging in Drug and Biologics Development
Book Subtitle
Fundamentals and Applications
Editors
  • Brian R. Moyer
  • Narayan P.S. Cheruvu
  • Tom Hu
Series Title
AAPS Advances in the Pharmaceutical Sciences Series
Series Volume
8
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
American Association of Pharmaceutical Scientists
eBook ISBN
978-1-4614-8247-5
DOI
10.1007/978-1-4614-8247-5
Hardcover ISBN
978-1-4614-8246-8
Softcover ISBN
978-1-4939-5174-1
Series ISSN
2210-7371
Edition Number
1
Number of Pages
XVII, 401
Number of Illustrations and Tables
24 b/w illustrations, 101 illustrations in colour
Topics