AAPS Advances in the Pharmaceutical Sciences Series

Transporters in Drug Development

Discovery, Optimization, Clinical Study and Regulation

Editors: Sugiyama, Yuichi, Steffansen, Bente (Eds.)

  • Answers key questions in drug development
  • Written by leaders in the field
  • Covers both pharmaceutical industry and FDA perspectives
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eBook $149.00
price for USA (gross)
  • ISBN 978-1-4614-8229-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-8228-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4939-5206-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

About the authors

Yuichi Sugiyama had been the Professor, Department of Molecular Pharmacokinetics at the University of Tokyo since 1991, retired from the University of Tokyo, 2012. He is now working as the Head of Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, Yokohama, Japan. He is a coauthor of more than 580 publications in international journals as well as 270 book chapters and review articles. His research focuses on two areas: 1) Physiologically based pharmacokinetics (In vitro/in vivo extrapolation): 2) Molecular pharmacokinetics of drug transport in liver, kidney, intestine and brain.

His work is internationally recognized by prestigious awards, including AAPS Distinguished Pharmaceutical Scientist Award, 2003, FIP Hoest Madsen Gold Medal in 2009, "Medal with Purple Ribbon" given by Government in 2010 and B.Brodie Award from ASPET in 2012. According to a recent report of ISI Essential Science Indicators, Professor Sugiyama has been ranked as the top (#1) cited scientist in the field of Pharmacology & Toxicology (1997-2007). He served as the chairman of Board of Pharmaceutical Sciences in FIP (2000-2004). He was also the president of both “International society for the study of xenobiotics (ISSX)” and “Japanese Society for Xenobiotic Metabolism and Disposition (JSSX)”.(2006-2007).

 

Bente Steffansen is Associate Professor in Transporters in ADME at The Faculty of Health and Medical Sciences, University of Copenhagen. She graduated with MSc (pharm) in 1989 from the Royal Danish School of Pharmacy and obtained her PhD in 1994 under the Danish Research Academy within the field of prodrug design aimed for improved drug delivery. During her PhD she was also a research scientist for 1½ year at the University of Kentucky, USA. She vent to the University of Uppsala in Sweden as visiting scientist in 1996. Shortly hereafter in 1997 she initiated the Molecular Biopharmaceutics research group at the University of Pharmaceutical Sciences focusing in the beginning on designing prodrugs for the absorptive peptide transporter PEPT1. Her interest for membrane transporters has since then expanded to include many other transporters. Bente has more than 60 research publications, supervised more than 120 Master students for their final research degree and 15 PhD’s. In 2010 she edited a book in Molecular Biopharmaceutis, she is a member of the European BioSim network of excellence, and has received several research grants including honorable travel grant. She serves as the Program Director for the Pharmaceutical education at the University of Copenhagen and is a member of the Chemical Committee under the National Pharmacopea Board.

Reviews

From the book reviews:

“A collection of chapters from the heavyweights of drug transporters, this book is likely to stand proud on the shelves of anyone in the field. … The text is very much aimed at those engrossed in the study of transporters and the tools available for their study. … The latest understanding of transporter-related drug-drug interactions is included, as well as an industrial perspective of transporters in ADME.” (Graham Lappin, bts News Magazine of The British Toxicology Society, Issue 1, June, 2014)


Table of contents (13 chapters)

  • Membrane Transporters in ADME

    Steffansen, Bente (et al.)

    Pages 1-22

  • In Vitro Kinetic Characterization of Transporter-Mediated Permeability

    Steffansen, Bente (et al.)

    Pages 23-35

  • In Vitro Characterization of Interactions with Drug Transporting Proteins

    Artursson, Per (et al.)

    Pages 37-65

  • In Vivo Characterization of Interactions on Transporters

    Kusuhara, Hiroyuki (et al.)

    Pages 67-97

  • Applications of Targeted Proteomics in ADME for IVIVE

    Balogh, Larissa M. (et al.)

    Pages 99-119

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4614-8229-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-8228-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4939-5206-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Transporters in Drug Development
Book Subtitle
Discovery, Optimization, Clinical Study and Regulation
Editors
  • Yuichi Sugiyama
  • Bente Steffansen
Series Title
AAPS Advances in the Pharmaceutical Sciences Series
Series Volume
7
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8229-1
DOI
10.1007/978-1-4614-8229-1
Hardcover ISBN
978-1-4614-8228-4
Softcover ISBN
978-1-4939-5206-9
Series ISSN
2210-7371
Edition Number
1
Number of Pages
XIII, 317
Number of Illustrations and Tables
28 b/w illustrations, 21 illustrations in colour
Topics