Epigenetics and Complex Traits

Editors: Naumova, Anna K., Greenwood, Celia MT (Eds.)

  • Focuses on the relationship between epigenetic changes and genetic changes in human disease ​
  • A resource for those working in human genetics to learn of the impact epigenetics has on inheritance    
  • Presents detailed and distinct views on the interplay between complex traits and epigenetics
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eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-8078-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-8077-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-4487-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book will provide an overview of basic epigenetic phenomena; interaction between epigenetic and genetic factors; and the influence of epigenetic factors on inheritance. Epigenetic states may contribute to the penetrance of genetic polymorphisms or mutations and thereby modify inheritance patterns. This may result in non‐Mendelian inheritance of genetic traits such as observed in common human disease. The relationship between epigenetics and genetics, however, has not been comprehensively summarized yet. The topic is being more and more appreciated lately due to considerable advances in genomic and epigenomic approaches to study the origins of human disease.   The editors will focus not only on describing epigenetic characteristics, mechanisms and results, but also on how considerations of epigenetics can alter interpretation and analysis of risks for complex traits. This book will be a resource for those who have been working in human genetics or analysis of human genetic data and are studying the impact of epigenetics on inheritance. An overview will be given of the impacts of inter‐individual variation in epigenetic states from major changes (errors in genomic imprinting) that cause congenital developmental defects to subtle changes and their impact on complex traits. The editors will discuss the relationship between epigenetic changes and genetic changes in human disease. Several chapters will also focus on statistical analysis of epigenetics effects, either in human disease genetic studies, or in population genetics. ​  

Table of contents (14 chapters)

  • Epigenetic Reprogramming in the Mammalian Germline

    Maupetit-Méhouas, Stéphanie (et al.)

    Pages 3-34

  • Establishment of Tissue-Specific Epigenetic States During Development

    Sandovici, Ionel

    Pages 35-62

  • X-Chromosome Inactivation

    Robinson, Wendy P. (et al.)

    Pages 63-88

  • Cis- and Trans-Effects Underlying Polar Overdominance at the Callipyge Locus

    Georges, Michel (et al.)

    Pages 89-106

  • Transgenerational Epigenetic Effects and Complex Inheritance Patterns

    Naumova, Anna K.

    Pages 107-129

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-8078-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-8077-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-4487-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Epigenetics and Complex Traits
Editors
  • Anna K. Naumova
  • Celia MT Greenwood
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-8078-5
DOI
10.1007/978-1-4614-8078-5
Hardcover ISBN
978-1-4614-8077-8
Softcover ISBN
978-1-4939-4487-3
Edition Number
1
Number of Pages
XXII, 341
Number of Illustrations and Tables
10 b/w illustrations, 33 illustrations in colour
Topics