Stearoyl-CoA Desaturase Genes in Lipid Metabolism

Editors: Ntambi, James M (Ed.)

  • First book to focus on SCD Genes in Lipid Metabolism
  • This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver, metabolism, Colitis, and more​
  • Gives an overview of the growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species
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eBook $149.00
price for USA (gross)
  • ISBN 978-1-4614-7969-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-7968-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans.   At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enzyme because it synthesizes oleate a well-known fatty acid that is abundant in many dietary sources. However numerous studies have shown that SCD is a very highly regulated enzyme that features in so many physiological processes ranging from fat differentiation, carbohydrate and fat metabolism, inflammation and cancer. The editor’s studies using stearoyl-CoA desaturase knockout (SCD1-/-) mice and studies of other investigators using pharmacological approaches to reduce SCD1 expression in mouse tissues have all established that the expression of SCD1 gene isoform represents a key step in partitioning of lipids between storage and oxidation. High SCD expression favors fat storage leading to obesity while reduced SCD expression favors fat burning and leanness. Although these studies clearly illustrated that SCD1 expression is involved in the development of obesity and insulin resistance, questions remain in the elucidation of the mechanisms involved and role of SCD1.   This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver metabolism, Colitis, and more. ​

Table of contents (15 chapters)

  • Early Studies on Role of Stearoyl-CoA Desaturase During Preadipocyte Differentiation

    Bernlohr, David A. (et al.)

    Pages 1-11

  • Skin Stearoyl-CoA Desaturase Genes

    Parimoo, Satish (et al.)

    Pages 13-25

  • Stearoyl-CoA Desaturase-1 Is a Biological Regulator of Energy Homeostasis

    Ntambi, James M.

    Pages 27-35

  • Role for Stearoyl-CoA Desaturase-1 in the Metabolic Effects of Leptin

    Cohen, Paul

    Pages 37-47

  • Regulation and Metabolic Functions of White Adipose Tissue Stearoyl-CoA Desaturase

    Kalupahana, Nishan Sudheera (et al.)

    Pages 49-60

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4614-7969-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-7968-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Stearoyl-CoA Desaturase Genes in Lipid Metabolism
Editors
  • James M Ntambi
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-7969-7
DOI
10.1007/978-1-4614-7969-7
Hardcover ISBN
978-1-4614-7968-0
Edition Number
1
Number of Pages
XI, 239
Topics