Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders

Editors: Van Bockstaele, Elisabeth J. (Ed.)

  • ​Content written by the leading experts in the field
  • Presents potential therapeutic applications
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About this book

The past decade has seen tremendous growth in the study of cannabinoid receptor signaling in brain.  The impact and consequences of cannabinoid modulation of monoaminergic (dopamine, norepinephrine, and serotonin) circuits is becoming more clear.  Scientists have shown significant interaction between these two systems in a variety of psychiatric and neurological disorders such as affective disorders, multiple sclerosis, and pain or pain disorders.  The overarching goal of Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders is to provide current information on advances in the field of endocannabinoid signaling and potential therapeutic applications with a particular emphasis on monoaminergic circuits.  ​

About the authors

Elisabeth Van Bockstaele is a Professor in the Department of Neuroscience and Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia, PA.  She obtained her PhD from New York University and conducted her postdoctoral work at Cornell University Medical College in New York City. She served as Vice-Chair of Research in the Department of Neurological Surgery and is the current founding Director of the Graduate Program in Neuroscience in the College of Biomedical and Graduate Studies at Thomas Jefferson University. She has served on multiple grant review panels including serving as Chair of the Neuroimmunology, Neuroendocrinology and Behavior Study Section at the National Institutes of Health and she served as Chair of the Membership and Chapters Committee of the Society for Neuroscience (SfN) and as a Member of the Committee on Neuroscience Departments and Programs and Professional Development Committee at SfN.  She was also a fellow in the Executive Leadership in Academic Medicine program at Drexel University College of Medicine. Dr. Van Bockstaele has devoted her scientific career to understanding the role of norepinephrine in stress-related illness, particularly as it relates to psychiatric disorders. Her research has primarily focused on preclinical studies examining the cellular adaptations of noradrenergic circuits to drugs of abuse (opiates, cannabinoids and psychostimulants) but more recently has expanded to include clinical investigations.  Ongoing research efforts are aimed at understanding stress-related psychiatric disorders, novel opiate detoxification approaches for counteracting norepinephrine over-activity following withdrawal from opiates as well as elucidating the impact of stress on vulnerability to substance abuse. Her laboratory is one of the only research groups studying interactions between the endocannabinoid and noradrenergic systems and her group employs state-of-the-art high-resolution neuroanatomical approaches with subcellular precision to understand the nature of state dependent interactions of this integrative system for the treatment of stress-induced anxiety disorders.

Reviews

From the reviews:

“This book reviews the expansion of our understanding of cannabinoid modulation of monoaminergic circuits and their interactions in a variety of psychiatric and neurological disorders. … intended for readers familiar with both clinical and preclinical research in this area, including individuals at all research, educational, and clinical levels interested in issues related to the use of cannabinoids for medical purposes. … a detailed and technical review of recent information on this receptor system and how it relates to a number of neurological and psychiatric disorders.” (Michael Easton, Doody’s Book Reviews, February, 2014)

Table of contents (14 chapters)

  • Endocannabinoids and Monoamines: Modulating the Modulators

    Van Bockstaele, Elisabeth J.

    Pages 1-9

  • Endocannabinoid-Mediated Synaptic Plasticity

    Mackie, Ken

    Pages 11-24

  • Current Cannabinoid Receptor Nomenclature and Pharmacological Principles

    Marcu, Jahan (et al.)

    Pages 25-54

  • Cue-Elicited Craving for Cannabis Activates the Reward Neurocircuitry Associated with the Neuropathology of Addiction

    DeWitt, Samuel J. (et al.)

    Pages 55-71

  • Cannabinoid Modulation of Dopaminergic Circuits in Neurodegenerative and Neuropsychiatric Disorders

    Matricon, Julien (et al.)

    Pages 73-101

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-7940-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-7939-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4899-9608-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders
Editors
  • Elisabeth J. Van Bockstaele
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-7940-6
DOI
10.1007/978-1-4614-7940-6
Hardcover ISBN
978-1-4614-7939-0
Softcover ISBN
978-1-4899-9608-4
Edition Number
1
Number of Pages
IX, 337
Topics