Systems Analysis of Chromatin-Related Protein Complexes in Cancer

Editors: Emili, Andrew, Greenblatt, Jack, Wodak, Shoshana (Eds.)

  • ​​Defining high-quality protein-protein interaction networks and the physical and functional characterization of the protein machines underlying the human chromatin interactome
  • Identification of RNA molecules associated with various chromatin-modifying machines that direct or regulate the complexes to various target genes
  • Exploring the biological significance of chromatin machines in cancer (and the development and differentiation of stem cells)​
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eBook $149.00
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  • ISBN 978-1-4614-7931-4
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Hardcover $189.00
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About this book

​​​​​​​​​​​​​​​​​​​​​​​

Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie  environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research.

Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized.

To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines  - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery.

What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.

Table of contents (16 chapters)

  • Networks of Histone Demethylases and Their Relevance to the Regulation of Chromatin Structure and Dynamics

    Marcon, Edyta (et al.)

    Pages 1-32

  • Histone Methyltransferase Complexes in Transcription, Development, and Cancer

    Olsen, Jonathan B. (et al.)

    Pages 33-47

  • Chromatin Biology and Cancer Linked Through Protein–Protein Interactions

    Pu, Shuye (et al.)

    Pages 49-63

  • Familial and Somatic Mutations of Histone-Modifying Enzymes in Cancer

    Liu, Chenyi (et al.)

    Pages 65-85

  • ncRNA–Protein Interactions in Development and Disease from the Perspective of High-Throughput Studies

    Zhao, Dorothy Yanling (et al.)

    Pages 87-115

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4614-7931-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-7930-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Systems Analysis of Chromatin-Related Protein Complexes in Cancer
Editors
  • Andrew Emili
  • Jack Greenblatt
  • Shoshana Wodak
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-7931-4
DOI
10.1007/978-1-4614-7931-4
Hardcover ISBN
978-1-4614-7930-7
Edition Number
1
Number of Pages
XI, 316
Topics