Protein Tyrosine Phosphatase Control of Metabolism

Editors: Bence, Kendra K. (Ed.)

  • Covers the identification of new phosphatases that are involved in metabolic control
  • Includes a review of tissue-specific effects of protein tyrosine phosphatase 1B
  • Book is timely given the growing epidemic of metabolic syndrome, obesity and diabetes
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eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-7855-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-7854-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular signaling pathways related to metabolism. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. Given the growing obesity and diabetes epidemics in the United States and throughout the world, the desire to identify possible therapeutic targets for treatment of these diseases is a high priority. In many ways, PTPs may be attractive drug targets since they are amenable to targeting with small molecules; however many challenges abound in making PTP inhibitors.

Table of contents (13 chapters)

  • Redox Regulation of PTPs in Metabolism: Focus on Assays

    Xu, Yang (et al.)

    Pages 1-26

  • Quantitative Modeling Approaches for Understanding the Role of Phosphatases in Cell Signaling Regulation: Applications in Metabolism

    Lazzara, Matthew J.

    Pages 27-48

  • Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism

    Xi, Yannan (et al.)

    Pages 49-69

  • PTP1B and TCPTP in CNS Signaling and Energy Balance

    Bence, Kendra K. (et al.)

    Pages 71-89

  • PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress

    Delibegovic, Mirela (et al.)

    Pages 91-105

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-4614-7855-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-1-4614-7854-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Protein Tyrosine Phosphatase Control of Metabolism
Editors
  • Kendra K. Bence
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-7855-3
DOI
10.1007/978-1-4614-7855-3
Hardcover ISBN
978-1-4614-7854-6
Edition Number
1
Number of Pages
XI, 273
Topics