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Biological and Medical Physics, Biomedical Engineering

Biophysics of the Failing Heart

Physics and Biology of Heart Muscle

Editors: Solaro, R. John, Tardiff, Jil C. (Eds.)

  • Consideration of heart failure with an emphasis on biophysics
  • Authors are clinicians who see patients and do research
  • A didactic approach of use in focused courses or sections of courses for advanced students
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eBook $99.00
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  • ISBN 978-1-4614-7678-8
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-1-4614-7677-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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About this book

Subjects in the monograph “Biophysics of the Failing Heart” include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.

About the authors

R. John Solaro is a Distinguished University Professor at the University of Illinois, Chicago and the head of the Physiology and Biophysics department.

Jil C. Tardiff is a Professor at the Department of Cellular and Molecular Medicine at the University of Arizona in Tucson. She is also a practicing cardiologist.

Reviews

From the reviews:

“This is an up-to-date synthesis of the molecular and cellular biophysics of both normal and various cardiac pathologies with an emphasis on heart failure. … It is designed as a useful resource for cardiology practitioners and basic scientists looking for a current in-depth review of cardiac molecular biophysiology. … The book is extensively illustrated with diagrams and figures. This is a necessary addition to the literature addressing the biophysiology in the failing heart. It will be useful to cardiovascular specialists and basic scientists.” (Don A. Davis, Doody’s Book Reviews, January, 2014)


Table of contents (11 chapters)

  • Introduction to the Biophysics of the Failing Heart

    Solaro, R. John (et al.)

    Pages 1-4

  • Sarcoplasmic Reticulum Ca Homeostasis and Heart Failure

    Zima, Aleksey V. (et al.)

    Pages 5-36

  • Ca-Homeostasis and Heart Failure: Focus on the Biophysics of Surface Membrane Ca-Fluxes

    Banach, Kathrin

    Pages 37-61

  • Biophysics of Membrane Currents in Heart Failure

    Liu, Man (et al.)

    Pages 63-90

  • Biophysical Mechanisms for the Metabolic Component of Impaired Heart Function

    Lewandowski, E. Douglas

    Pages 91-121

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-1-4614-7678-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-1-4614-7677-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Biophysics of the Failing Heart
Book Subtitle
Physics and Biology of Heart Muscle
Editors
  • R. John Solaro
  • Jil C. Tardiff
Series Title
Biological and Medical Physics, Biomedical Engineering
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-7678-8
DOI
10.1007/978-1-4614-7678-8
Hardcover ISBN
978-1-4614-7677-1
Series ISSN
1618-7210
Edition Number
1
Number of Pages
VI, 253
Topics