Advances in Experimental Medicine and Biology

Viral Entry into Host Cells

Editors: Pöhlmann, Stefan, Simmons, Graham (Eds.)

  • Provides a comprehensive overview of interplay between viral and cellular factors during virus entry
  • Reviews key processes underlying host cell entry of viruses
  • Discusses cellular entry of reoviruses
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About this book

For a virus to invade a host cell it needs to penetrate the physical barrier imposed by the plasma membrane. Viruses have evolved specialized surface proteins to meet this challenge. These proteins facilitate delivery of the viral genetic information into the host cell by either fusing the viral envelope with a host cell membrane or by forming membrane pores. Membrane fusion and pore formation critically depend on the engagement of host cell receptors and receptor choice is a key determinant of viral tropism. The multi-faceted interplay between viral and cellular factors during virus entry is a fascinating field of study, which can provide important insight into viral pathogenesis and define new targets for intervention. This book provides a comprehensive overview of this exciting field of research.

About the authors

STEFA N PÖHLMANN is Professor for Infection Biology and Head of the Infection Biology Unit of the German Primate Center. His research is focused on virus host cell interactions, particularly on the molecular processes underlying host cell entry of human immunodeficiency virus and emerging viruses. Stefan Pöhlmann received his academic degrees (Dr. rer. nat., venia legendi) from the Friedrich‑Alexander‑University Erlangen‑Nurnberg. Before his appointment at the German Primate Center, he worked as a postdoctoral fellow at the University of Pennsylvania, as a junior research group leader at the Friedrich‑Alexander‑University Erlangen‑Nurnberg and as an assistant professor at Hannover Medical School. He serves on the editorial board of the Journal of Virology and Virology and serves as academic editor for PLoS ONE.

GRAHAM SIMMONS is an Associate Investigator at Blood Systems Research Institute and Associate Professor in the Department of Laboratory Medicine at the University of California, San Francisco. He is interested in many aspects of viral entry, particularly for blood transfusion transmissible agents and other emerging and re‑emerging viruses that may be a threat to the blood supply. Graham Simmons received his doctoral training from the Institute of Cancer Research in London prior to performing an EMBO‑sponsored postdoctoral fellowship at the University of Pennsylvania.

Table of contents (10 chapters)

  • Attachment Factors

    Jolly, Clare L. (et al.)

    Pages 1-23

  • Picornavirus Entry

    Bergelson, Jeffrey M. (et al.)

    Pages 24-41

  • Reovirus Receptors, Cell Entry, and Proapoptotic Signaling

    Danthi, Pranav (et al.)

    Pages 42-71

  • Entry of Influenza Virus

    Sun, Xiangjie (et al.)

    Pages 72-82

  • Filovirus Entry

    Simmons, Graham

    Pages 83-94

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-7651-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-7650-4
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
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Bibliographic Information

Bibliographic Information
Book Title
Viral Entry into Host Cells
Editors
  • Stefan Pöhlmann
  • Graham Simmons
Series Title
Advances in Experimental Medicine and Biology
Series Volume
790
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Landes Bioscience and Springer Science+Business Media New York
eBook ISBN
978-1-4614-7651-1
DOI
10.1007/978-1-4614-7651-1
Hardcover ISBN
978-1-4614-7650-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVII, 199
Topics