War in the Body

The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines

Authors: Wick, W David, Yang, Otto O

  • Explores the rapid and profound evolution of the HIV virus
  • Considers the divergent viewpoints on why and how the virus evolves
  • Addresses the ramifications of this evolution on the immune system, as well as vaccines
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eBook $269.00
price for USA (gross)
  • ISBN 978-1-4614-7294-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.00
price for USA
  • ISBN 978-1-4614-7293-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $349.00
price for USA
  • ISBN 978-1-4899-9255-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In the relatively few decades since the introduction of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species. This book will consider these evolutionary variations, as well as the different and, at times, opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the virus's evolution, and the implications of these for vaccine development. The issue will be explored and explained through "ecological genetics," which postulates that all living organisms have, besides rivals, enemies. This is divergent from the more traditional school of "population genetics," which emphasizes that evolution occurs among rival species (or variants thereof) that compete for niches or resources in a fixed, unreactive environment. Both models will be formulated using mathematical models, which will be included in the book. Finally, it will consider the possibilities for designing a vaccine that blocks HIV from escaping the immune system.

About the authors

Dr. Yang is a well known T-Cell and HIV expert at UCLA. Dr. Wick is recently retired. His last position was Senior Scientist in the Infectious Diseases Division of the Fred Hutchison Center, in Seattle, where he worked on immune response to HIV and vaccines.

Reviews

From the reviews:

“Provide a critical overview of the mathematical modeling performed so far to understand HIV immunity and escape, and advance an innovative alternative approach for stochastic simulation. … War in the Body is not a how-to guide, tutorial, or cook-book, but a research monograph, with thought exercises to cultivate problem-solving skills and foster developing plausible, stable numerical simulations.” (Complexity, March, 2014)


Table of contents (26 chapters)

Buy this book

eBook $269.00
price for USA (gross)
  • ISBN 978-1-4614-7294-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.00
price for USA
  • ISBN 978-1-4614-7293-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $349.00
price for USA
  • ISBN 978-1-4899-9255-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
War in the Body
Book Subtitle
The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines
Authors
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-7294-0
DOI
10.1007/978-1-4614-7294-0
Hardcover ISBN
978-1-4614-7293-3
Softcover ISBN
978-1-4899-9255-0
Edition Number
1
Number of Pages
XIX, 298
Number of Illustrations and Tables
47 b/w illustrations, 4 illustrations in colour
Topics