Resistance to Targeted Anti-Cancer Therapeutics

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy

Targeted Therapies to Reverse Resistance

Editors: Bonavida, Benjamin (Ed.)

  • ​​​​​​​​​​Describes the main mechanisms that govern tumor cell resistance to apoptotic stimuli
  • Demonstrates the identification of existing agents or the development of new agents that can serve as sensitizing agents with other cytotoxics
  • Features the latest research on the results of combining targeted sensitizing agents and conventional cytotoxic therapies
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eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-7070-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-7069-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

​​​​​This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.

About the authors

Dr. Benjamin Bonavida is a professor at UCLA's David Geffen School of Medicine for the Department of Microbiology, Immunology, & Molecular Genetics. His other appointments include being a member of the Department of Defense Congressionally Directed Medical Research Program, Member of the National Cancer Institute's SPORE Program, member of the International Scientific Advisory Board of the Israel Cancer Research Foundation, to name a few. He's currently a scientific reviewer for several journals and a member of editorial boards including Journal of Clinical Immunology, International Journal of Oncology, and Cancer Biotherapy & Radiopharmaceuticals. In his career, he's published over 450 papers and reviews, and he's also edited two books with Springer in the past. For more information, please see the CV attached herewith.

Table of contents (13 chapters)

  • Multidrug Resistance in Cancer: A Tale of ABC Drug Transporters

    Kapoor, Khyati (et al.)

    Pages 1-34

  • Multidrug Resistance: A Role for Membrane Physics, pH and Drug Transporters

    Daniel, Chloe (et al.)

    Pages 35-46

  • Mechanisms and Potential Therapies for Acquired Resistance to Inhibitors Targeting the Raf or MEK Kinases in Cancer

    Freeman, Alyson K. (et al.)

    Pages 47-67

  • Mechanisms of Resistance to Targeted B-Raf Therapies

    Tantravahi, Ramana V. (et al.)

    Pages 69-88

  • Role of β1 Integrins in the Complication and Drug Resistance Against Lung Cancer: Targeting β1 Integrins to Eradicate Lung Cancer

    Mukhopadhyay, Srirupa (et al.)

    Pages 89-108

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-7070-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-7069-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy
Book Subtitle
Targeted Therapies to Reverse Resistance
Editors
  • Benjamin Bonavida
Series Title
Resistance to Targeted Anti-Cancer Therapeutics
Series Volume
1
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-7070-0
DOI
10.1007/978-1-4614-7070-0
Hardcover ISBN
978-1-4614-7069-4
Series ISSN
2196-5501
Edition Number
1
Number of Pages
XIII, 260
Topics