SpringerBriefs in Cancer Research

MHC Class I Antigens In Malignant Cells

Immune Escape And Response To Immunotherapy

Authors: Aptsiauri, Natalia, Garcia-Lora, Angel Miguel, Cabrera, Teresa

  • Discusses molecular mechanisms of total or partial loss of the MHC class I antigens in cancer cells
  • Explains the role of MHC class I defects in cancer progression
  • Shows the correlation of MHC class I altered phenotypes with resistance to Immunotherapy ​
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eBook $34.99
price for USA (gross)
  • ISBN 978-1-4614-6543-0
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  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.95
price for USA
  • ISBN 978-1-4614-6542-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy.  Precise identification of the mechanism leading to MHC class I defects  will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used. According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on determining the final outcome of cancer immunotherapy. This SpringerBrief will present how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy. ​  

About the authors

Teresa Cabrera Castillo, Ph.D., MD., is a Full Professor at the Department of Biochemistry, Molecular Biology, and Immunology at the University of Granada and a Medical Immunology Specialist at Hospital Universitario Virgen de las Nieves. Natalia Aptsiauri, Ph.D., MD., is a Senior Staff Scientist at the Department of Clinical Analysis and Immunology, University Hospital Virgen de las Nieves Angel Miguel Garcia Lora, Ph.D., is a Senior Staff Scientist at the Department of Clinical Analysis and Immunology, University Hospital Virgen de las Nieves Please see attached CVs for more detail.

Table of contents (5 chapters)

  • Overview of MHC Class I Antigens

    Aptsiauri, Natalia (et al.)

    Pages 1-11

  • HLA Class I Expression in Human Cancer

    Aptsiauri, Natalia (et al.)

    Pages 13-30

  • MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns

    Aptsiauri, Natalia (et al.)

    Pages 31-45

  • Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression

    Aptsiauri, Natalia (et al.)

    Pages 47-50

  • Conclusions

    Aptsiauri, Natalia (et al.)

    Pages 51-51

Buy this book

eBook $34.99
price for USA (gross)
  • ISBN 978-1-4614-6543-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.95
price for USA
  • ISBN 978-1-4614-6542-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
MHC Class I Antigens In Malignant Cells
Book Subtitle
Immune Escape And Response To Immunotherapy
Authors
Series Title
SpringerBriefs in Cancer Research
Series Volume
1
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Maria Teresa Cabrera Castillo
eBook ISBN
978-1-4614-6543-0
DOI
10.1007/978-1-4614-6543-0
Softcover ISBN
978-1-4614-6542-3
Edition Number
1
Number of Pages
VIII, 51
Number of Illustrations and Tables
3 b/w illustrations, 14 illustrations in colour
Topics