Vesicle Trafficking in Cancer

Editors: Yarden, Yosef, Tarcic, Gabi (Eds.)

  • Discusses the evolutionary basis of endocytic pathways
  • Examines the lipid composition of the endosomal pathway
  • Explore mathematical modeling of endocytosis
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eBook $189.00
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  • ISBN 978-1-4614-6528-7
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Hardcover $249.00
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valid through November 5, 2017
  • ISBN 978-1-4614-6527-0
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Softcover $249.00
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  • ISBN 978-1-4899-9496-7
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About this book

Endocytosis and vesicular trafficking determine the landscape of the cell’s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer.

Table of contents (17 chapters)

  • Clathrin-Mediated Endocytosis

    Sorkin, Alexander (et al.)

    Pages 1-31

  • Intimate and Facultative? Regulation of Clathrin-Mediated Endocytosis by the Actin Cytoskeleton

    Hirschhorn, Tal (et al.)

    Pages 33-56

  • Oncogenic Signaling from the Plasma Membrane

    Zamir, Eli (et al.)

    Pages 57-74

  • Endocytosis in the Spatial Control of Polarised Cell Functions

    Scita, Giorgio (et al.)

    Pages 75-94

  • Aberrant Vesicular Trafficking Contributes to Altered Polarity and Metabolism in Cancer

    Mitra, Shreya (et al.)

    Pages 95-123

Buy this book

eBook $189.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-1-4614-6528-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4614-6527-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4899-9496-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Vesicle Trafficking in Cancer
Editors
  • Yosef Yarden
  • Gabi Tarcic
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-6528-7
DOI
10.1007/978-1-4614-6528-7
Hardcover ISBN
978-1-4614-6527-0
Softcover ISBN
978-1-4899-9496-7
Edition Number
1
Number of Pages
XIV, 393
Topics