Pharmacoresistance in Epilepsy

From Genes and Molecules to Promising Therapies

Editors: Rocha, Luisa, Cavalheiro, Esper A. (Eds.)

  • Contains the most up-to-date information on the development of pharmacoresistance in epileptic disorders
  • Discusses novel therapeutic strategies to counteract the development of pharmacoresistance
  • Of interest to both basic scientists and clinicians​
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eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-6464-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-6463-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-9504-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease.

Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoesistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.”

Table of contents (20 chapters)

  • Pharmacoresistance and Epilepsy

    Rubio-Donnadieu, Francisco

    Pages 1-9

  • Genes Involved in Pharmacoresistant Epilepsy

    Martínez-Juárez, Iris E. (et al.)

    Pages 11-25

  • Pathological Oscillations in the Pharmacoresistant Epileptic Brain

    Staba, Richard J.

    Pages 27-46

  • Molecular Mechanisms of Pharmacoresistant Epilepsy

    Lazarowski, Alberto (et al.)

    Pages 47-57

  • Modifications in the Seizures Susceptibility by Excitotoxic Neuronal Damage and Its Possible Relationship with the Pharmacoresistance

    Ureña-Guerrero, Monica E. (et al.)

    Pages 59-76

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4614-6464-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4614-6463-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-9504-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pharmacoresistance in Epilepsy
Book Subtitle
From Genes and Molecules to Promising Therapies
Editors
  • Luisa Rocha
  • Esper A. Cavalheiro
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-6464-8
DOI
10.1007/978-1-4614-6464-8
Hardcover ISBN
978-1-4614-6463-1
Softcover ISBN
978-1-4899-9504-9
Edition Number
1
Number of Pages
XII, 329
Topics