Stress-Induced Mutagenesis

Editors: Mittelman, David (Ed.)

  • Covers pathways of stress-induced mutagenesis in all systems
  • Serves a wide audience
  • Examines changed ideas about mutation and evolution
see more benefits

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-6280-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-4614-6279-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4899-9418-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes.

This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.

Table of contents (13 chapters)

  • Stress-Induced Mutagenesis in Bacteria

    Matic, Ivan

    Pages 1-19

  • Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress

    Shee, Chandan (et al.)

    Pages 21-39

  • Transcription-Mediated Mutagenic Processes

    Robleto, Eduardo (et al.)

    Pages 41-57

  • Transposon Mutagenesis in Disease, Drug Discovery, and Bacterial Evolution

    Zhang, Zhongge (et al.)

    Pages 59-77

  • Hsp90 as a Capacitor of Both Genetic and Epigenetic Changes in the Genome During Cancer Progression and Evolution

    Lu, Xiangyi (et al.)

    Pages 79-101

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-6280-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-4614-6279-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4899-9418-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Stress-Induced Mutagenesis
Editors
  • David Mittelman
Copyright
2013
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-6280-4
DOI
10.1007/978-1-4614-6280-4
Hardcover ISBN
978-1-4614-6279-8
Softcover ISBN
978-1-4899-9418-9
Edition Number
1
Number of Pages
XV, 275
Topics