Androgen-Responsive Genes in Prostate Cancer

1. Front Matter

   Pages i-ix

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2. Roles of Androgen Receptor Coregulators and Cell Signaling in the Regulation of Androgen-Responsive Genes

   • Irina U. Agoulnik, Nancy L. Weigel

   Pages 1-11

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3. Selective and Classical Androgen Response Elements in Androgen-Regulated Gene Expression

   • Frank Claessens, Liesbeth Clinckemalie, Helsen Christine, Lien Spans, Vanessa Dubois, Michaël Laurent et al.

   Pages 13-27

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4. Negative Androgen-Response Elements in Androgen Target Genes

   • Wei Qi, Zhengxin Wang

   Pages 29-41

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5. Chromatin Looping and Long Distance Regulation by Androgen Receptor

   • Benjamin Sunkel, Qianben Wang

   Pages 43-58

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6. The Functionality of Prostate Cancer Predisposition Risk Regions Is Revealed by AR Enhancers

   • Houtan Noushmehr, Simon G. Coetzee, Suhn K. Rhie, Chunli Yan, Gerhard A. Coetzee

   Pages 59-84

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7. Mechanisms of ARE-Independent Gene Activation by the Androgen Receptor in Prostate Cancer Cells: Potential Targets for Better Intervention Strategies

   • Manohar Ratnam, Mugdha Patki, Mesfin Gonit, Robert Trumbly

   Pages 85-100

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8. Androgen Action, Wnt Signaling, and Prostate Tumorigenesis

   • Zijie Sun, Suk Hyung Lee

   Pages 101-116

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9. Toward Revealing the Complexity of Androgen-Responsive Protein and Noncoding Transcripts in Prostate Cancer

   • Melanie L. Lehman, Colleen C. Nelson

   Pages 117-134

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10. Androgen-Responsive Gene Expression in Prostate Cancer Progression

    • Amy H. Tien, Marianne D. Sadar

    Pages 135-153

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11. Androgen Receptor-Regulated Genes in Prostate Cancer Initiation Versus Metastasis

    • Soo Ok Lee, Chiung-Kuei Huang, Luo Jie, Chawnshang Chang

    Pages 155-176

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12. Androgen-Independent Induction of Androgen-Responsive Genes by Interleukin-6 Regulation

    • Zoran Culig

    Pages 177-185

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13. The Effect of AR Overexpression on Androgen Signaling in Prostate Cancer

    • Alfonso Urbanucci, Kati K. Waltering, Ian G. Mills, Tapio Visakorpi

    Pages 187-200

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14. The Expression Signature of Androgen Receptor Splice Variants and Their Distinctive Transcriptional Activities in Castration-Resistant Prostate Cancer

    • Stephen R. Plymate, Jun Luo

    Pages 201-213

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15. Androgen Regulation of the Cell Cycle in Prostate Cancer

    • Haojie Huang

    Pages 215-225

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16. Androgen Receptor Signaling Interactions Control Epithelial–Mesenchymal Transition (EMT) in Prostate Cancer Progression

    • Sarah K. Martin, Michael V. Fiandalo, Natasha Kyprianou

    Pages 227-255

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17. Androgen Receptor Regulation of Serum Response Factor Signaling in Prostate Cancer

    • Alissa R. Verone, Hannelore V. Heemers

    Pages 257-271

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18. Regulation of Angiogenesis by Androgen-Responsive Gene EAF2

    • Laura E. Pascal, Zhou Wang

    Pages 273-283

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19. The Role of miR-21, an Androgen-Regulated MicroRNA, in Prostate Cancer

    • Judit Ribas, Shawn E. Lupold

    Pages 285-305

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20. Androgen-Dependent Oncogenic Activation of ETS Transcription Factors by Recurrent Gene Fusions in Prostate Cancer: Biological and Clinical Implications

    • Albert Dobi, Taduru Sreenath, Shiv Srivastava

    Pages 307-328

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Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males.  AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes.  Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer.   This volume provides critical information from  well respected experts in the field.  Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT).  Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function.  This book is intended for researchers, scientists, faculty, and advanced graduate students  with an interest in androgen action and prostate cancer.​  

• androgen action
• androgen receptor coregulators
• chromatin looping
• miR-21
• prostate tumorigenesis
• gene therapy

• , Shadyside Medical Center, University of Pittsburgh, Pittsburgh, USA

  Zhou Wang

The volume editor, Dr. Zhou Wang, is well-noted in the field of prostate cancer and he is theChair for Urological Research at the University of Pittsburgh Medical Center, as well as the co-director of Urological and Prostate Cancer Program at the University of Pittsburgh Cancer Institute.He has also conducted several scientific reviews for several top journals in the area of cancer research.

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