Oxidative Stress in Applied Basic Research and Clinical Practice

Studies on Arthritis and Joint Disorders

Editors: Alcaraz, Maria Jose, Gualillo, Oreste, Sánchez-Pernaute, Olga (Eds.)

  • Describes the most current diagnostic tools, laboratory methods and technology
  • Provides specific coverage on emerging technology and medical applications
  • Promotes the concept of using biomarkers representative of oxidative stress reactions and free radical damage
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Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-6166-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA
  • ISBN 978-1-4614-6165-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA
  • ISBN 978-1-4899-8882-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This next volume in our established series proposes to systematically review the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress”, in the pathology of arthritis and other joint diseases. It will describe the most current diagnostic tools , laboratory methods and technology, to suggest ways of prevention and treatment and to emphasize the concept of the bench-to-bedside approach. The book will also provide specific coverage on emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents and several more relevant aspects. In addition, the book will promote the concept of using biomarkers representative of oxidative stress reactions and free radical damage , as well as describe the effect of antioxidants in treating disease in clinical trials. The content will be valuable to researchers studying the development of arthritis/joint disease, and clinicians treating patients with these diagnoses.

About the authors

María José Alcaraz, Ph.D., is a full Professor in Pharmacology  at the Department of Pharmacology, University of Valencia, Spain, and former Head of this Department. After completing her Ph.D. at the University of Valencia with Extraordinary Award, she undertook postdoctoral research funded by the Spanish Ministery of Education at the Department of Pharmacology, King's Col. London (1983-1984).  She also worked as a visiting researcher at the Unité 348 INSERM, Paris (1998) and received  the Dr. Esteve Foundation Award to the best publication in pharmacology and Almirall Award to the best project in pharmacology.  In addition to act as editor or referee for several international journals and expert for scientific projects evaluation in different countries and international organizations,  she has played an active role in international cooperation with Latin America. Maria José Alcaraz is the head of the “Pharmacology of Inflammation” group, Department of Pharmacology, University of Valencia, Spain, which focuses on the pathogenesis of the inflammatory process, oxidative stress regulation and the development of new therapeutic targets for the treatment of joint diseases mainly rheumatoid arthritis and osteoarthritis.  

Dr. Oreste Gualillo obtained his PhD in Pharmacology at the Department of Experimental Pharmacology of the University “Federico II”, Naples (Italy). He received training in molecular endocrinology under Prof. Paul A. Kelly at the Necker School of Medicine, Paris. In 1998 he moved to the Laboratory of Molecular Endocrinology of the University of Santiago de Compostela, Spain, where he worked as a Marie Curie postdoctoral research fellow. In 2001 he set up his own research group at the Santiago University Clinical Hospital. He is currently a Class “A” Stable researcher with the SERGAS (Servizo Galegode Saude) and Carlos III Health Institute of the Spanish Ministry of Health, heading the NEIRID (NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases) research laboratory of the Santiago University Clinical Hospital at the IDIS (Instituto de Investigación Sanitaria) of Santiago de Compostela. He has published over 80 papers and in the last years his research was focussed on defining the multifaceted role of adipokines in chondrocyte pathophysiology.

 

Olga Sánchez-Pernaute, MD, PhD, is a senior rheumatologist in the Jimenez Diaz Foundation University Hospital and assistant Prof at the Autonoma University School of Medicine in Madrid. She has a dilated background in translational research, focused on the study of innate mechanisms of disease associated to autoimmune rheumatic conditions. Of note are her early contributions to the field of inflammatory mediators in experimental models of arthritis, and the pioneer work on the role of fibrin in the progression of synovitis. She was invited for a one-year fellowship at the Laboratory of Experimental Rheumatology of Zürich University, where she developed her research interest in epigenetics. In the last few years she has created a Multidisciplinary Unit for Systemic Autoimmune Diseases that she currently directs at her Institution.

Reviews

From the reviews:

“This is a thorough overview of the role of oxidative damage in joint and connective tissue disease. This is a highly specialized area that is important for rheumatologists as well as for basic scientists to understand. … book is appropriate for all practitioners and academicians who are interested in the role of oxidative damage in joint disorders. … The authors do a great job of connecting basic science concepts with clinical disease. … easy to read, and diagrams and charts are clear and used appropriately.” (Jonathan Miner, Doody’s Book Reviews, July, 2013)

Table of contents (21 chapters)

  • Soluble Proteomic Biomakers in the Management of Arthritis

    Henrotin, Yves (et al.)

    Pages 3-31

  • Regulation of T-Cell Functions by Oxidative Stress

    Bennett, Stuart J. (et al.)

    Pages 33-48

  • Nitric Oxide and the Respiratory Chain in Synovial Cells and Chondrocytes

    López-Armada, María J. (et al.)

    Pages 49-66

  • Adipokines, Molecular Players at the Crossroad Between Inflammation and Oxidative Stress: Role in Arthropathies

    Scotece, Morena (et al.)

    Pages 67-88

  • Regulation of Cartilage and Bone Metabolism by Oxidative Stress

    Niehoff, Anja (et al.)

    Pages 89-108

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4614-6166-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA
  • ISBN 978-1-4614-6165-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA
  • ISBN 978-1-4899-8882-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Studies on Arthritis and Joint Disorders
Editors
  • Maria Jose Alcaraz
  • Oreste Gualillo
  • Olga Sánchez-Pernaute
Series Title
Oxidative Stress in Applied Basic Research and Clinical Practice
Copyright
2013
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-6166-1
DOI
10.1007/978-1-4614-6166-1
Hardcover ISBN
978-1-4614-6165-4
Softcover ISBN
978-1-4899-8882-9
Series ISSN
2197-7224
Edition Number
1
Number of Pages
XII, 411
Number of Illustrations and Tables
26 b/w illustrations, 15 illustrations in colour
Topics