Cardiac Remodeling

1. Front Matter

   Pages i-xi

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2. Molecular Mechanisms of Remodeling in Pressure and Volume Overload Hypertrophy and Heart Failure

   1. Front Matter

      Pages 1-1

      PDF

   2. β-Adrenergic Receptor Signaling in Heart Failure

      • Grace Jung Ah Lee, Lin Yan, Dorothy E. Vatner, Stephen F. Vatner

      Pages 3-30

   3. Remodeling of Potassium Channels in Cardiac Hypertrophy

      • Tetsuo Sasano, Junko Kurokawa

      Pages 31-45

   4. Role of Gender in Ca2+ Cycling and Cardiac Remodeling Due to Heart Failure

      • Naranjan S. Dhalla, Amrit Malik, Shelly Zieroth, Paramjit S. Tappia

      Pages 47-64

   5. The Failing Heart: Is It an Inefficient Engine or an Engine Out of Fuel?

      • Waleed G. T. Masoud, Alexander S. Clanachan, Gary D. Lopaschuk

      Pages 65-84

   6. Regulation of Cardiac Hypertrophic Remodeling by the USP15/SLIM1 Pathway

      • Hiroto Nakajima

      Pages 85-96

   7. Role of Galectin-3 Pathways in the Pathogenesis of Cardiac Remodeling and Heart Failure

      • Lili Yu, Rudolf A. de Boer

      Pages 97-111

   8. A Mitochondriocentric Pathway to Cardiomyocyte Necrosis: An Upstream Molecular Mechanism in Myocardial Fibrosis

      • Adedayo A. Adeboye, Kevin P. Newman, Dwight A. Dishmon, Shadwan Alsafwah, Syamal K. Bhattacharya, Karl T. Weber

      Pages 113-125

   9. The ACE2/Ang (1–7) Pathway in Cardiac Remodeling Due to Pressure Overload

      • Seyyed M. R. Kazemi-Bajestani, Vaibhav B. Patel, Wang Wang, Gavin Y. Oudit

      Pages 127-139

   10. Local Actions of Natriuretic Peptides and Nitric Oxide in Cardiac Remodeling: Implications for Therapy

       • Michaela Kuhn, Hitoshi Nakagawa

       Pages 141-158

   11. Modulating G Protein-Coupled Receptors to Effect Reverse Cardiac Remodeling

       • Cinzia Perrino, Howard A. Rockman

       Pages 159-177

   12. Role of Inflammation and Matrix Proteinases in Cardiac Remodeling Following Stress and Injury

       • Davy Vanhoutte, Stephane Heymans

       Pages 179-200

   13. Role of Chymase in Matrix and Myocardial Remodeling Due to Mitral Regurgitation: Implications for Therapy

       • Spencer J. Melby, Carlos M. Ferrario, Chih-Cheng Wei, Louis J. Dell’Italia

       Pages 201-214

   14. Cardiac Remodeling Due to Aortic Regurgitation and Mitral Regurgitation

       • Blase A. Carabello

       Pages 215-226

   15. Reducing Oxidative Stress and Manipulating Molecular Signaling Events Using Resveratrol as a Therapy for Pathological Cardiac Hypertrophy

       • Shereen M. Hamza, Miranda M. Sung, Jason R. B. Dyck

       Pages 227-254

   16. Angiogenesis, Arteriogenesis, and Mitochondrial Dysfunction

       • M. S. McMurtry

       Pages 255-272

3. Molecular Mechanisms of Remodeling After Myocardial Injury and Infarction

   1. Front Matter

      Pages 273-273

      PDF

   2. Subcellular Remodeling and Cardiac Dysfunction Due to Ischemia–Reperfusion Injury

      • Naranjan S. Dhalla, Vijayan Elimban, Larry Hryshko, Darren H. Freed

      Pages 275-291

   3. Role of MicroRNAs in Cardiac Hypertrophy and Postinfarction Remodeling

      • Jian Ding, Da-Zhi Wang

      Pages 293-311

The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.

• cardiac function
• cardiac hypertrophy
• heart failure
• ischemia
• myocardial infarction
• reperfusion

• Walter MacKenzie Health Sciences Centre, Division of Cardiology, University of Alberta, Edmonton, Canada

  Bodh I. Jugdutt

• St. Boniface General Hospital Research C, Institute of Cardiovascular Sciences, Winnipeg, Canada

  Naranjan S. Dhalla

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