Advances in Experimental Medicine and Biology

Tumor Microenvironment and Cellular Stress

Signaling, Metabolism, Imaging, and Therapeutic Targets

Editors: Koumenis, Constantinos, Hammond, Ester, Giaccia, Amato (Eds.)

  • Explores significant advances in understanding the genetic determinants of stress responses​
  • Discusses various cellular and animal models of tumor microenvironment study
  • Features novel targets for imaging and therapeutic intervention
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Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4614-5915-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-5914-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4939-4705-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

About the authors

Constantinos Koumenis, Ph.D. is an Associate Professor, Vice Chair and Research Division Director and Co-Leader, Radiation Biology & Imaging Program at the University of Pennsylvania, School of Medicine. Amato Giacca,Ph.D., is a Professor and Director of the Department of Radiation Oncology, Leader of Radation Biology and Molecular Therapeutics Program at the Stanford Cancer Center. Ester Hammond Ph.D., is a Junior Group Leader at Gray Institute for Radiation Oncology and Biology at Oxford University.

Table of contents (12 chapters)

  • Hypoxia and Metabolism in Cancer

    Bensaad, Karim (et al.)

    Pages 1-39

  • Hypoxia and Regulation of Cancer Cell Stemness

    Yun, Zhong (et al.)

    Pages 41-53

  • Hypoxia-Mediated Metastasis

    Chang, Joan (et al.)

    Pages 55-81

  • Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell’s Perspective

    Rivera, Lee (et al.)

    Pages 83-99

  • Hypoxic VDAC1: A Potential Mitochondrial Marker for Cancer Therapy

    Brahimi-Horn, M. Christiane (et al.)

    Pages 101-110

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4614-5915-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4614-5914-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4939-4705-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Microenvironment and Cellular Stress
Book Subtitle
Signaling, Metabolism, Imaging, and Therapeutic Targets
Editors
  • Constantinos Koumenis
  • Ester Hammond
  • Amato Giaccia
Series Title
Advances in Experimental Medicine and Biology
Series Volume
772
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4614-5915-6
DOI
10.1007/978-1-4614-5915-6
Hardcover ISBN
978-1-4614-5914-9
Softcover ISBN
978-1-4939-4705-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 290
Number of Illustrations and Tables
8 b/w illustrations, 30 illustrations in colour
Topics